Cesium-induced atrial tachycardia degenerating into atrial fibrillation in dogs: Atrial torsades de pointes?

Tadashi Satoh, Douglas P. Zipes

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Atrial Torsades de Pointes? Introduction: In this study, we investigated whether the potassium channel blocker, cesium chloride (CsCl), which is capable of producing early afterdepolarizations (EADs) and polymorphic ventricular tachyarrhythmias resembling torsades de pointes, might exert similar effects in the atria. Methods and Results: In nine anesthetized open chest dogs, 5 mL of CsCl in incremental doses (0.05, 0.1, 0.15, 0.2, 0.25 mM/mL) was injected into the sinus node artery to induce atrial arrhythmias. A polymorphic atrial tachycardia (P-AT) apparently triggered by an EAD and degenerating into atrial fibrillation resulted after CsCl administration in six dogs, but not in the remaining three dogs at any dose of CsCl. The P-AT developed during a normal atrial rate (110 ± 13.5 beats/min) on six occasions and during atrial bradycardia (58.6 ± 17.9 beat/min) five times. P-AT that occurred during a normal atrial rate had the last normal P wave temporally closely related to ventricular activation, with a VA interval of almost zero (1.3 ± 3.3 msec), whereas P-AT induced from an atrial bradycardia had no relation to ventricular activation. The %EAD in the atrial bradycardia group (13.9 ± 2.5) exceeded that in the normal atrial rate group (10.9 ± 1.8) (P < 0.05). Conclusion: CsCl induces atrial EADs that provoke P-AT that degenerates into atrial fibrillation. P-AT has some characteristics similar to ventricular torsades de pointes.

Original languageEnglish (US)
Pages (from-to)970-975
Number of pages6
JournalJournal of cardiovascular electrophysiology
Volume9
Issue number9
DOIs
StatePublished - 1998

Keywords

  • Arrhythmia
  • Atrium
  • Cesium
  • Fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

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