Challenges for Providing Effective Hemostasis in Surgery and Trauma

Jeffrey H. Lawson, Michael Murphy

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Vascular injury, whether surgical or traumatic, triggers a complex series of regulatory events. The understanding of these events, their interdependence, and their effect on hemostasis and thrombosis, is slowly being unraveled. The current understanding of these processes is reviewed in this paper. The application of this knowledge to the operating theatre has been slow and is severely limited by the lack of effective tools to monitor the coagulopathic status of individual patients. Hence, the initial treatment of patients with severe hemorrhage relles on improving the patient's physiological status and on basic surgical techniques. Should these efforts fall, then a number of topical hemostatic agents, selective inhibitors of fibrinolysis, and procoagulant molecules, such as recombinant factor VIIa, may be utilized. However, many of these agents have not yet been tested in clinical trials and studies are urgently needed to determine efficacy, safety, optimal dosage and time of administration.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalSeminars in Hematology
Volume41
Issue number1 SUPPL. 1
StatePublished - Jan 2004
Externally publishedYes

Fingerprint

Hemostasis
Wounds and Injuries
Vascular System Injuries
Fibrinolysis
Hemostatics
Thrombosis
Clinical Trials
Hemorrhage
Safety
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Challenges for Providing Effective Hemostasis in Surgery and Trauma. / Lawson, Jeffrey H.; Murphy, Michael.

In: Seminars in Hematology, Vol. 41, No. 1 SUPPL. 1, 01.2004, p. 55-64.

Research output: Contribution to journalArticle

Lawson, Jeffrey H. ; Murphy, Michael. / Challenges for Providing Effective Hemostasis in Surgery and Trauma. In: Seminars in Hematology. 2004 ; Vol. 41, No. 1 SUPPL. 1. pp. 55-64.
@article{ff2512b69a0b43fb938d358a7714f331,
title = "Challenges for Providing Effective Hemostasis in Surgery and Trauma",
abstract = "Vascular injury, whether surgical or traumatic, triggers a complex series of regulatory events. The understanding of these events, their interdependence, and their effect on hemostasis and thrombosis, is slowly being unraveled. The current understanding of these processes is reviewed in this paper. The application of this knowledge to the operating theatre has been slow and is severely limited by the lack of effective tools to monitor the coagulopathic status of individual patients. Hence, the initial treatment of patients with severe hemorrhage relles on improving the patient's physiological status and on basic surgical techniques. Should these efforts fall, then a number of topical hemostatic agents, selective inhibitors of fibrinolysis, and procoagulant molecules, such as recombinant factor VIIa, may be utilized. However, many of these agents have not yet been tested in clinical trials and studies are urgently needed to determine efficacy, safety, optimal dosage and time of administration.",
author = "Lawson, {Jeffrey H.} and Michael Murphy",
year = "2004",
month = "1",
language = "English (US)",
volume = "41",
pages = "55--64",
journal = "Seminars in Hematology",
issn = "0037-1963",
publisher = "W.B. Saunders Ltd",
number = "1 SUPPL. 1",

}

TY - JOUR

T1 - Challenges for Providing Effective Hemostasis in Surgery and Trauma

AU - Lawson, Jeffrey H.

AU - Murphy, Michael

PY - 2004/1

Y1 - 2004/1

N2 - Vascular injury, whether surgical or traumatic, triggers a complex series of regulatory events. The understanding of these events, their interdependence, and their effect on hemostasis and thrombosis, is slowly being unraveled. The current understanding of these processes is reviewed in this paper. The application of this knowledge to the operating theatre has been slow and is severely limited by the lack of effective tools to monitor the coagulopathic status of individual patients. Hence, the initial treatment of patients with severe hemorrhage relles on improving the patient's physiological status and on basic surgical techniques. Should these efforts fall, then a number of topical hemostatic agents, selective inhibitors of fibrinolysis, and procoagulant molecules, such as recombinant factor VIIa, may be utilized. However, many of these agents have not yet been tested in clinical trials and studies are urgently needed to determine efficacy, safety, optimal dosage and time of administration.

AB - Vascular injury, whether surgical or traumatic, triggers a complex series of regulatory events. The understanding of these events, their interdependence, and their effect on hemostasis and thrombosis, is slowly being unraveled. The current understanding of these processes is reviewed in this paper. The application of this knowledge to the operating theatre has been slow and is severely limited by the lack of effective tools to monitor the coagulopathic status of individual patients. Hence, the initial treatment of patients with severe hemorrhage relles on improving the patient's physiological status and on basic surgical techniques. Should these efforts fall, then a number of topical hemostatic agents, selective inhibitors of fibrinolysis, and procoagulant molecules, such as recombinant factor VIIa, may be utilized. However, many of these agents have not yet been tested in clinical trials and studies are urgently needed to determine efficacy, safety, optimal dosage and time of administration.

UR - http://www.scopus.com/inward/record.url?scp=0842299504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0842299504&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 55

EP - 64

JO - Seminars in Hematology

JF - Seminars in Hematology

SN - 0037-1963

IS - 1 SUPPL. 1

ER -