Challenges in pre-clinical testing of anti-cancer drugs in cell culture and in animal models

Harm Hogenesch, Alexander Yu Nikitin

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Experiments with cultures of human tumor cell lines, xenografts of human tumors into immunodeficient mice, and mouse models of human cancer are important tools in the development and testing of anti-cancer drugs. Tumors are complex structures composed of genetically and phenotypically heterogeneous cancer cells that interact in a reciprocal manner with the stromal microenvironment and the immune system. Modeling the complexity of human cancers in cell culture and in mouse models for preclinical testing is a challenge that has not yet been met although tremendous advances have been made. A combined approach of cell culture and mouse models of human cancer is most likely to predict the efficacy of novel anti-cancer treatments in human clinical trials.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalJournal of Controlled Release
Volume164
Issue number2
DOIs
StatePublished - Dec 10 2012
Externally publishedYes

Keywords

  • Cancer model
  • Cell culture
  • Mouse
  • Preclinical
  • Xenograft

ASJC Scopus subject areas

  • Pharmaceutical Science

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