Challenges of targeting vascular stability in acute kidney injury

Research output: Contribution to journalComment/debate

7 Scopus citations


Acute kidney injury following folate administration is characterized by a vascular remodeling that is initially proliferative but subsequently results in vascular endothelial loss. Interventions directed toward promoting endothelial growth may preserve vascular structure and therefore renal function. However, angiopoietin-1 therapy in the setting of folate-induced acute kidney injury resulted in an expanded fibrotic response despite apparent preservation of the vasculature, indicating that renal repair responses are complex and vascular-directed therapies should be approached with caution.

Original languageEnglish (US)
Pages (from-to)257-258
Number of pages2
JournalKidney international
Issue number3
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Nephrology

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