Changes in antigen-specific cytokine and chemokine responses to Plasmodium falciparum antigens in a highland area of kenya after a prolonged absence of malaria exposure

Lyticia A. Ochola, Cyrus Ayieko, Lily Kisia, Ng'wena G. Magak, Estela Shabani, Collins Ouma, Chandy John

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Individuals naturally exposed to Plasmodium falciparum lose clinical immunity after a prolonged lack of exposure. P. falciparum antigen-specific cytokine responses have been associated with protection from clinical malaria, but the longevity of P. falciparum antigen-specific cytokine responses in the absence of exposure is not well characterized. A highland area of Kenya with low and unstable malaria transmission provided an opportunity to study this question. The levels of antigen-specific cytokines and chemokines associated in previous studies with protection from clinical malaria (gamma interferon [IFN-γ], interleukin-10 [IL-10], and tumor necrosis factor alpha [TNF-α]), with increased risk of clinical malaria (IL-6), or with pathogenesis of severe disease in malaria (IL-5 and RANTES) were assessed by cytometric bead assay in April 2008, October 2008, and April 2009 in 100 children and adults. During the 1-year study period, none had an episode of clinical P. falciparum malaria. Two patterns of cytokine responses emerged, with some variation by antigen: a decrease at 6 months (IFN-γ and IL-5) or at both 6 and 12 months (IL-10 and TNF-α) or no change over time (IL-6 and RANTES). These findings document that P. falciparum antigen-specific cytokine responses associated in prior studies with protection from malaria (IFN-γ, TNF-α, and IL-10) decrease significantly in the absence of P. falciparum exposure, whereas those associated with increased risk of malaria (IL-6) do not. The study findings provide a strong rationale for future studies of antigen-specific IFN-γ, TNF-α, and IL-10 responses as biomarkers of increased population-level susceptibility to malaria after prolonged lack of P. falciparum exposure.

Original languageEnglish (US)
Pages (from-to)3775-3782
Number of pages8
JournalInfection and Immunity
Volume82
Issue number9
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Kenya
Plasmodium falciparum
Chemokines
Malaria
Cytokines
Antigens
Interleukin-10
Tumor Necrosis Factor-alpha
Interferons
Interleukin-6
Chemokine CCL5
Falciparum Malaria
Interleukin-5
Antigenic Variation
Interferon-gamma
Immunity
Biomarkers
Population

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Parasitology
  • Infectious Diseases

Cite this

Changes in antigen-specific cytokine and chemokine responses to Plasmodium falciparum antigens in a highland area of kenya after a prolonged absence of malaria exposure. / Ochola, Lyticia A.; Ayieko, Cyrus; Kisia, Lily; Magak, Ng'wena G.; Shabani, Estela; Ouma, Collins; John, Chandy.

In: Infection and Immunity, Vol. 82, No. 9, 2014, p. 3775-3782.

Research output: Contribution to journalArticle

Ochola, Lyticia A. ; Ayieko, Cyrus ; Kisia, Lily ; Magak, Ng'wena G. ; Shabani, Estela ; Ouma, Collins ; John, Chandy. / Changes in antigen-specific cytokine and chemokine responses to Plasmodium falciparum antigens in a highland area of kenya after a prolonged absence of malaria exposure. In: Infection and Immunity. 2014 ; Vol. 82, No. 9. pp. 3775-3782.
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AU - Magak, Ng'wena G.

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AB - Individuals naturally exposed to Plasmodium falciparum lose clinical immunity after a prolonged lack of exposure. P. falciparum antigen-specific cytokine responses have been associated with protection from clinical malaria, but the longevity of P. falciparum antigen-specific cytokine responses in the absence of exposure is not well characterized. A highland area of Kenya with low and unstable malaria transmission provided an opportunity to study this question. The levels of antigen-specific cytokines and chemokines associated in previous studies with protection from clinical malaria (gamma interferon [IFN-γ], interleukin-10 [IL-10], and tumor necrosis factor alpha [TNF-α]), with increased risk of clinical malaria (IL-6), or with pathogenesis of severe disease in malaria (IL-5 and RANTES) were assessed by cytometric bead assay in April 2008, October 2008, and April 2009 in 100 children and adults. During the 1-year study period, none had an episode of clinical P. falciparum malaria. Two patterns of cytokine responses emerged, with some variation by antigen: a decrease at 6 months (IFN-γ and IL-5) or at both 6 and 12 months (IL-10 and TNF-α) or no change over time (IL-6 and RANTES). These findings document that P. falciparum antigen-specific cytokine responses associated in prior studies with protection from malaria (IFN-γ, TNF-α, and IL-10) decrease significantly in the absence of P. falciparum exposure, whereas those associated with increased risk of malaria (IL-6) do not. The study findings provide a strong rationale for future studies of antigen-specific IFN-γ, TNF-α, and IL-10 responses as biomarkers of increased population-level susceptibility to malaria after prolonged lack of P. falciparum exposure.

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