Changes in immunohistochemical staining in prostatic adenocarcinoma following diethylstilbestrol therapy

David Grignon, M. Troster

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Twenty-eight pretreatment and posttreatment biopsies from 11 cases of prostatic adenocarcinoma were stained for prostate-specific acid phosphatase (PAP), prostate-specific antigen (PSA), and keratin to determine the effect of hormonal (diethylstilbestrol) therapy on these immunological markers. Treatment intervals ranged from 2 to 63 months. All pretreatment tumors were strongly positive for PAP, and nine were strongly positive for PSA. Two were weakly positive for PSA, and all were negative for keratin. In five of the 11 posttreatment group cases, staining with both PAP and PSA was reduced. In three posttreatment cases, the malignant epithelium showed a squamoid appearance, and in these areas the keratin gave a positive reaction. These findings indicate that immunohistochemical staining with PAP and PSA may change in response to hormonal therapy. These alterations may lead to false-negative results when using these techniques to identify the primary tumor source of metastatic deposits of prostatic carcinoma.

Original languageEnglish (US)
Pages (from-to)195-202
Number of pages8
JournalProstate
Volume7
Issue number2
StatePublished - 1985
Externally publishedYes

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Diethylstilbestrol
Prostate-Specific Antigen
Acid Phosphatase
Adenocarcinoma
Staining and Labeling
Prostate
Keratins
Therapeutics
Neoplasms
Epithelium
Carcinoma
Biopsy

ASJC Scopus subject areas

  • Urology

Cite this

Changes in immunohistochemical staining in prostatic adenocarcinoma following diethylstilbestrol therapy. / Grignon, David; Troster, M.

In: Prostate, Vol. 7, No. 2, 1985, p. 195-202.

Research output: Contribution to journalArticle

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