Changes in structure and function of rat kidney slices produced by low sodium

A. P. Evan, Y. S. Park, S. Solomon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of a low Na medium on PAH transport, renal morphology, and acetate stimulation of PAH transport have been studied. Low Na inhibits PAH uptake and induces vacuolar formation in tubular cells. Both processes are reversible by reincubating in a high Na medium. Vacuolization appears temperature dependent being much greater at 37 than at 25 degr. C. Acetate uptake consists of a passive and an active component, neither of which is sodium dependent. Acetate stimulation of PAH uptake does, however, require Na. This latter observation suggests that Na may act by altering cell metabolism.

Original languageEnglish (US)
Pages (from-to)209-220
Number of pages12
JournalNephron
Volume21
Issue number4
StatePublished - Dec 1 1978

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Acetates
Sodium
Kidney
Observation
Temperature

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

Cite this

Changes in structure and function of rat kidney slices produced by low sodium. / Evan, A. P.; Park, Y. S.; Solomon, S.

In: Nephron, Vol. 21, No. 4, 01.12.1978, p. 209-220.

Research output: Contribution to journalArticle

Evan, AP, Park, YS & Solomon, S 1978, 'Changes in structure and function of rat kidney slices produced by low sodium', Nephron, vol. 21, no. 4, pp. 209-220.
Evan, A. P. ; Park, Y. S. ; Solomon, S. / Changes in structure and function of rat kidney slices produced by low sodium. In: Nephron. 1978 ; Vol. 21, No. 4. pp. 209-220.
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