Changes in the properties of adenylate cyclase from guinea pig lungs in tuberculosis

M. S. Bortnik, Alexander Skurat, I. R. Eshba

Research output: Contribution to journalArticle

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Abstract

Changes in the properties of adenylate cyclase from the lungs of tuberculotic guinea pigs were revealed. The number of β-adrenergic receptors in the lungs was found to be reduced by 30% at the second and by 70% at the third stage of the disease. The degree and the value of K(a) for adenylate cyclase activation by isoproterenol remained thereby unchanged. The basal activity of adenylate cyclase was increased by 20% over the control level at the second stage and decreased by 20% at the third stage of the disease. At these periods, the stimulating effects of guanylyl imidodiphosphate, NaF and forskolin on lung adenylate cyclase were diminished. The experimental results point to the significant role of the enzymes of cAMP metabolism and reflect the course of the tuberculosis process in experimental animals.

Original languageEnglish (US)
Pages (from-to)589-594
Number of pages6
JournalBiokhimiya
Volume50
Issue number4
StatePublished - 1985
Externally publishedYes

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Adenylyl Cyclases
Guanylyl Imidodiphosphate
Level control
Colforsin
Isoproterenol
Metabolism
Adrenergic Receptors
Animals
Chemical activation
Enzymes

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Changes in the properties of adenylate cyclase from guinea pig lungs in tuberculosis. / Bortnik, M. S.; Skurat, Alexander; Eshba, I. R.

In: Biokhimiya, Vol. 50, No. 4, 1985, p. 589-594.

Research output: Contribution to journalArticle

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