Characteristics of cerebrospinal fluid neuropeptides relevant to clinical research

Wade H. Berrettini, Gabriella Oxenstierna, Göran Sedvall, John Nurnberger, Philip W. Gold, David R. Rubinow, Lynn R. Goldin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Studies of human cerebrospinal fluid (CSF) peptides were conducted in an attempt to broaden the utility of CSF peptide determinations in psychiatric research. Healthy volunteers had two lumbar punctures, at least 3 weeks apart, to assess reproducibility within subjects. CSF levels of eight peptides were reliably reproducible, indicating that longitudinal studies of these CSF neuropeptides are feasible. Levels of 10 peptides were determined in four sequential 8 ml aliquots of CSF. CSF rostrocaudal gradients were not found for any of these 10 peptides. Neuropeptide Y (NPY), growth hormone releasing factor (GHRF), and corticotropin releasing factor (CRF) were measured in CSF from twins and brothers. CSF NPY levels were heritable, while CRF and GHRF levels were influenced more by environment. CSF levels of CRF, β-lipotropin, vasoactive intestinal peptide, adrenocorticotropic hormone, and somatostatin were highly correlated with one another, suggesting that a common factor is responsible for a significant proportion of the observed variance in their CSF levels. These results suggest that CSF peptide measurements may have a broad range of applicability to clinical psychiatric research.

Original languageEnglish
Pages (from-to)349-359
Number of pages11
JournalPsychiatry Research
Volume25
Issue number3
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Neuropeptides
Cerebrospinal Fluid
Research
Corticotropin-Releasing Hormone
Peptides
Growth Hormone-Releasing Hormone
Neuropeptide Y
Psychiatry
beta-Lipotropin
Spinal Puncture
Peptide Hormones
Vasoactive Intestinal Peptide
Somatostatin
Adrenocorticotropic Hormone
Longitudinal Studies
Siblings
Healthy Volunteers

Keywords

  • cerebrospinal fluid
  • Neurotransmitters
  • peptides

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Berrettini, W. H., Oxenstierna, G., Sedvall, G., Nurnberger, J., Gold, P. W., Rubinow, D. R., & Goldin, L. R. (1988). Characteristics of cerebrospinal fluid neuropeptides relevant to clinical research. Psychiatry Research, 25(3), 349-359. https://doi.org/10.1016/0165-1781(88)90104-7

Characteristics of cerebrospinal fluid neuropeptides relevant to clinical research. / Berrettini, Wade H.; Oxenstierna, Gabriella; Sedvall, Göran; Nurnberger, John; Gold, Philip W.; Rubinow, David R.; Goldin, Lynn R.

In: Psychiatry Research, Vol. 25, No. 3, 1988, p. 349-359.

Research output: Contribution to journalArticle

Berrettini, WH, Oxenstierna, G, Sedvall, G, Nurnberger, J, Gold, PW, Rubinow, DR & Goldin, LR 1988, 'Characteristics of cerebrospinal fluid neuropeptides relevant to clinical research', Psychiatry Research, vol. 25, no. 3, pp. 349-359. https://doi.org/10.1016/0165-1781(88)90104-7
Berrettini, Wade H. ; Oxenstierna, Gabriella ; Sedvall, Göran ; Nurnberger, John ; Gold, Philip W. ; Rubinow, David R. ; Goldin, Lynn R. / Characteristics of cerebrospinal fluid neuropeptides relevant to clinical research. In: Psychiatry Research. 1988 ; Vol. 25, No. 3. pp. 349-359.
@article{6d3e807f22b34940946b08f4b9f36dc7,
title = "Characteristics of cerebrospinal fluid neuropeptides relevant to clinical research",
abstract = "Studies of human cerebrospinal fluid (CSF) peptides were conducted in an attempt to broaden the utility of CSF peptide determinations in psychiatric research. Healthy volunteers had two lumbar punctures, at least 3 weeks apart, to assess reproducibility within subjects. CSF levels of eight peptides were reliably reproducible, indicating that longitudinal studies of these CSF neuropeptides are feasible. Levels of 10 peptides were determined in four sequential 8 ml aliquots of CSF. CSF rostrocaudal gradients were not found for any of these 10 peptides. Neuropeptide Y (NPY), growth hormone releasing factor (GHRF), and corticotropin releasing factor (CRF) were measured in CSF from twins and brothers. CSF NPY levels were heritable, while CRF and GHRF levels were influenced more by environment. CSF levels of CRF, β-lipotropin, vasoactive intestinal peptide, adrenocorticotropic hormone, and somatostatin were highly correlated with one another, suggesting that a common factor is responsible for a significant proportion of the observed variance in their CSF levels. These results suggest that CSF peptide measurements may have a broad range of applicability to clinical psychiatric research.",
keywords = "cerebrospinal fluid, Neurotransmitters, peptides",
author = "Berrettini, {Wade H.} and Gabriella Oxenstierna and G{\"o}ran Sedvall and John Nurnberger and Gold, {Philip W.} and Rubinow, {David R.} and Goldin, {Lynn R.}",
year = "1988",
doi = "10.1016/0165-1781(88)90104-7",
language = "English",
volume = "25",
pages = "349--359",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Characteristics of cerebrospinal fluid neuropeptides relevant to clinical research

AU - Berrettini, Wade H.

AU - Oxenstierna, Gabriella

AU - Sedvall, Göran

AU - Nurnberger, John

AU - Gold, Philip W.

AU - Rubinow, David R.

AU - Goldin, Lynn R.

PY - 1988

Y1 - 1988

N2 - Studies of human cerebrospinal fluid (CSF) peptides were conducted in an attempt to broaden the utility of CSF peptide determinations in psychiatric research. Healthy volunteers had two lumbar punctures, at least 3 weeks apart, to assess reproducibility within subjects. CSF levels of eight peptides were reliably reproducible, indicating that longitudinal studies of these CSF neuropeptides are feasible. Levels of 10 peptides were determined in four sequential 8 ml aliquots of CSF. CSF rostrocaudal gradients were not found for any of these 10 peptides. Neuropeptide Y (NPY), growth hormone releasing factor (GHRF), and corticotropin releasing factor (CRF) were measured in CSF from twins and brothers. CSF NPY levels were heritable, while CRF and GHRF levels were influenced more by environment. CSF levels of CRF, β-lipotropin, vasoactive intestinal peptide, adrenocorticotropic hormone, and somatostatin were highly correlated with one another, suggesting that a common factor is responsible for a significant proportion of the observed variance in their CSF levels. These results suggest that CSF peptide measurements may have a broad range of applicability to clinical psychiatric research.

AB - Studies of human cerebrospinal fluid (CSF) peptides were conducted in an attempt to broaden the utility of CSF peptide determinations in psychiatric research. Healthy volunteers had two lumbar punctures, at least 3 weeks apart, to assess reproducibility within subjects. CSF levels of eight peptides were reliably reproducible, indicating that longitudinal studies of these CSF neuropeptides are feasible. Levels of 10 peptides were determined in four sequential 8 ml aliquots of CSF. CSF rostrocaudal gradients were not found for any of these 10 peptides. Neuropeptide Y (NPY), growth hormone releasing factor (GHRF), and corticotropin releasing factor (CRF) were measured in CSF from twins and brothers. CSF NPY levels were heritable, while CRF and GHRF levels were influenced more by environment. CSF levels of CRF, β-lipotropin, vasoactive intestinal peptide, adrenocorticotropic hormone, and somatostatin were highly correlated with one another, suggesting that a common factor is responsible for a significant proportion of the observed variance in their CSF levels. These results suggest that CSF peptide measurements may have a broad range of applicability to clinical psychiatric research.

KW - cerebrospinal fluid

KW - Neurotransmitters

KW - peptides

UR - http://www.scopus.com/inward/record.url?scp=0023814832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023814832&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(88)90104-7

DO - 10.1016/0165-1781(88)90104-7

M3 - Article

C2 - 3186863

AN - SCOPUS:0023814832

VL - 25

SP - 349

EP - 359

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -