Characteristics of noninvoluting congenital hemangioma

A retrospective review

Pristine W. Lee, Ilona J. Frieden, Jenna L. Streicher, Timothy McCalmont, Anita Haggstrom

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background Noninvoluting congenital hemangioma (NICH) is a distinct vascular tumor of infancy. Objective We describe the clinical characteristics, histopathology, imaging, and natural history of NICH and compare our findings with previous reports. Methods We conducted a retrospective review of charts and photographic databases from 2 vascular anomaly centers over a 15-year period. Results Thirty cases of NICH were identified. All patients had fully formed vascular lesions at birth that demonstrated a nonprogressive course. The trunk and lower extremities were preferred sites and there was a female predominance. Thirteen of 30 patients reported pain. Focal necrosis and scarring was seen in a minority. Doppler studies, when performed, confirmed high vascular flow. Microscopic evaluation of 4 excised lesions showed lobular areas of endothelial cell proliferation directly adjacent to ectatic malformed vessels. Immunohistochemical studies demonstrated absence of glucose transporter-1 protein expression in every case. Wilms tumor-1 positivity was observed in lobular areas. The larger vessels did not stain with Wilms tumor-1, but some displayed D2-40 positivity. Limitations Patients were referred to university-based pediatric vascular anomaly centers, with potential bias toward more severe or extensive cases. Conclusions This retrospective study highlights the unique clinical and histopathologic features of NICH.

Original languageEnglish
Pages (from-to)899-903
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume70
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Hemangioma
Blood Vessels
Wilms Tumor
Facilitative Glucose Transport Proteins
Natural History
Cicatrix
Lower Extremity
Necrosis
Coloring Agents
Endothelial Cells
Retrospective Studies
Cell Proliferation
Parturition
Databases
Pediatrics
Pain
Neoplasms
Proteins

Keywords

  • infantile hemangiomas
  • noninvoluting congenital hemangioma
  • vascular tumors

ASJC Scopus subject areas

  • Dermatology

Cite this

Characteristics of noninvoluting congenital hemangioma : A retrospective review. / Lee, Pristine W.; Frieden, Ilona J.; Streicher, Jenna L.; McCalmont, Timothy; Haggstrom, Anita.

In: Journal of the American Academy of Dermatology, Vol. 70, No. 5, 2014, p. 899-903.

Research output: Contribution to journalArticle

Lee, Pristine W. ; Frieden, Ilona J. ; Streicher, Jenna L. ; McCalmont, Timothy ; Haggstrom, Anita. / Characteristics of noninvoluting congenital hemangioma : A retrospective review. In: Journal of the American Academy of Dermatology. 2014 ; Vol. 70, No. 5. pp. 899-903.
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