Characteristics of peripapillary retinal nerve fiber layer in preterm children

Jingyun Wang, Rand Spencer, Joel N. Leffler, Eileen E. Birch

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose: To examine quantitatively characteristics of the peripapillary retinal nerve fiber layer (RNFL) in preterm children using Fourier-domain optical coherence tomography (FD-OCT). Design: Prospective cross-sectional study. Methods: A 3-mm high-resolution FD-OCT peripapillary RNFL circular scan centered on the optic disc was obtained from right eyes of 25 preterm children (10.6 ± 3.7 years old, 8 preterm and 17 with regressed retinopathy of prematurity with normal-appearing posterior poles) and 54 full-term controls (9.8 ± 3.2 years old). Images were analyzed using Spectralis FD-OCT software to obtain average thickness measurements for 6 sectors (temporal superior, temporal, temporal inferior, nasal inferior, nasal, nasal superior), and the global average. Results: The RNFL global average for preterm children was 8% thinner than for full-term controls. In the preterm group, peripapillary RNFL thickness on the temporal side of the disc was 6% thicker than in full-term controls, while all other peripapillary RNFL sectors were 9% to 13% thinner. In the preterm group, temporal sector peripapillary RNFL thickness was correlated with gestational age (r = -0.47, P

Original languageEnglish (US)
JournalAmerican Journal of Ophthalmology
Volume153
Issue number5
DOIs
StatePublished - May 2012
Externally publishedYes

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Nerve Fibers
Optical Coherence Tomography
Nose
Retinopathy of Prematurity
Optic Disk
Gestational Age
Software
Cross-Sectional Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Characteristics of peripapillary retinal nerve fiber layer in preterm children. / Wang, Jingyun; Spencer, Rand; Leffler, Joel N.; Birch, Eileen E.

In: American Journal of Ophthalmology, Vol. 153, No. 5, 05.2012.

Research output: Contribution to journalArticle

Wang, Jingyun ; Spencer, Rand ; Leffler, Joel N. ; Birch, Eileen E. / Characteristics of peripapillary retinal nerve fiber layer in preterm children. In: American Journal of Ophthalmology. 2012 ; Vol. 153, No. 5.
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