Characteristics of pseudoexfoliation in the Thessaloniki eye study

Eleftherios Anastasopoulos, Fotis Topouzis, M. Roy Wilson, Alon Harris, Theofanis Pappas, Fei Yu, Archimidis Koskosas, Panayiota Founti, Anne L. Coleman

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

PURPOSE: To report on the prevalence of pseudoexfoliation (PEX) and its association with ophthalmic characteristics and systemic diseases in a well-defined population. METHODS: The Thessaloniki Eye study is a cross-sectional population-based study of chronic eye diseases in Thessaloniki, Greece. Participants with PEX were identified by clinical examination and were compared with those without PEX with regards to ophthalmic characteristics and systemic diseases, after adjusting for age and sex. RESULTS: PEX was found in 11.9% of the 2261 clinic-visit participants. Participants with PEX, compared with those without, had higher intraocular pressure, larger vertical cup-to-disc ratio, and higher percentage with vertical cup-to-disc ratio asymmetry and optic disc damage. The proportion with glaucoma among pseudoexfoliative participants (15.2%) was higher than that for glaucoma among nonpseudoexfoliative participants (4.7%). After excluding glaucoma participants, the only difference was the 0.6 mm Hg higher intraocular pressure in participants with PEX. Compared with nonpseudoexfoliative eyes, the presence of PEX on iris only or on both iris and lens was associated with higher intraocular pressure, whereas the presence of PEX on lens only was not. PEX was not associated with any systemic disease. CONCLUSIONS: The prevalence of PEX in Greece is relatively high compared with other white populations. PEX was associated with higher intraocular pressure and higher percentage with optic disc damage, secondary to the higher proportion with glaucoma among pseudoexfoliative participants than among nonpseudoexfoliative participants. In nonglaucoma participants, eyes with PEX had only slightly higher intraocular pressure, but this was not observed in eyes with PEX on lens only.

Original languageEnglish
Pages (from-to)160-166
Number of pages7
JournalJournal of Glaucoma
Volume20
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Intraocular Pressure
Glaucoma
Exfoliation Syndrome
Greece
Optic Disk
Iris
Population
Eye Diseases
Ambulatory Care
Lenses
Chronic Disease

Keywords

  • glaucoma
  • intraocular pressure
  • population-based study
  • pseudoexfoliation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Anastasopoulos, E., Topouzis, F., Wilson, M. R., Harris, A., Pappas, T., Yu, F., ... Coleman, A. L. (2011). Characteristics of pseudoexfoliation in the Thessaloniki eye study. Journal of Glaucoma, 20(3), 160-166. https://doi.org/10.1097/IJG.0b013e3181d9d8bd

Characteristics of pseudoexfoliation in the Thessaloniki eye study. / Anastasopoulos, Eleftherios; Topouzis, Fotis; Wilson, M. Roy; Harris, Alon; Pappas, Theofanis; Yu, Fei; Koskosas, Archimidis; Founti, Panayiota; Coleman, Anne L.

In: Journal of Glaucoma, Vol. 20, No. 3, 03.2011, p. 160-166.

Research output: Contribution to journalArticle

Anastasopoulos, E, Topouzis, F, Wilson, MR, Harris, A, Pappas, T, Yu, F, Koskosas, A, Founti, P & Coleman, AL 2011, 'Characteristics of pseudoexfoliation in the Thessaloniki eye study', Journal of Glaucoma, vol. 20, no. 3, pp. 160-166. https://doi.org/10.1097/IJG.0b013e3181d9d8bd
Anastasopoulos, Eleftherios ; Topouzis, Fotis ; Wilson, M. Roy ; Harris, Alon ; Pappas, Theofanis ; Yu, Fei ; Koskosas, Archimidis ; Founti, Panayiota ; Coleman, Anne L. / Characteristics of pseudoexfoliation in the Thessaloniki eye study. In: Journal of Glaucoma. 2011 ; Vol. 20, No. 3. pp. 160-166.
@article{517fa59b316046f49b6c5f399742dc67,
title = "Characteristics of pseudoexfoliation in the Thessaloniki eye study",
abstract = "PURPOSE: To report on the prevalence of pseudoexfoliation (PEX) and its association with ophthalmic characteristics and systemic diseases in a well-defined population. METHODS: The Thessaloniki Eye study is a cross-sectional population-based study of chronic eye diseases in Thessaloniki, Greece. Participants with PEX were identified by clinical examination and were compared with those without PEX with regards to ophthalmic characteristics and systemic diseases, after adjusting for age and sex. RESULTS: PEX was found in 11.9{\%} of the 2261 clinic-visit participants. Participants with PEX, compared with those without, had higher intraocular pressure, larger vertical cup-to-disc ratio, and higher percentage with vertical cup-to-disc ratio asymmetry and optic disc damage. The proportion with glaucoma among pseudoexfoliative participants (15.2{\%}) was higher than that for glaucoma among nonpseudoexfoliative participants (4.7{\%}). After excluding glaucoma participants, the only difference was the 0.6 mm Hg higher intraocular pressure in participants with PEX. Compared with nonpseudoexfoliative eyes, the presence of PEX on iris only or on both iris and lens was associated with higher intraocular pressure, whereas the presence of PEX on lens only was not. PEX was not associated with any systemic disease. CONCLUSIONS: The prevalence of PEX in Greece is relatively high compared with other white populations. PEX was associated with higher intraocular pressure and higher percentage with optic disc damage, secondary to the higher proportion with glaucoma among pseudoexfoliative participants than among nonpseudoexfoliative participants. In nonglaucoma participants, eyes with PEX had only slightly higher intraocular pressure, but this was not observed in eyes with PEX on lens only.",
keywords = "glaucoma, intraocular pressure, population-based study, pseudoexfoliation",
author = "Eleftherios Anastasopoulos and Fotis Topouzis and Wilson, {M. Roy} and Alon Harris and Theofanis Pappas and Fei Yu and Archimidis Koskosas and Panayiota Founti and Coleman, {Anne L.}",
year = "2011",
month = "3",
doi = "10.1097/IJG.0b013e3181d9d8bd",
language = "English",
volume = "20",
pages = "160--166",
journal = "Journal of Glaucoma",
issn = "1057-0829",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Characteristics of pseudoexfoliation in the Thessaloniki eye study

AU - Anastasopoulos, Eleftherios

AU - Topouzis, Fotis

AU - Wilson, M. Roy

AU - Harris, Alon

AU - Pappas, Theofanis

AU - Yu, Fei

AU - Koskosas, Archimidis

AU - Founti, Panayiota

AU - Coleman, Anne L.

PY - 2011/3

Y1 - 2011/3

N2 - PURPOSE: To report on the prevalence of pseudoexfoliation (PEX) and its association with ophthalmic characteristics and systemic diseases in a well-defined population. METHODS: The Thessaloniki Eye study is a cross-sectional population-based study of chronic eye diseases in Thessaloniki, Greece. Participants with PEX were identified by clinical examination and were compared with those without PEX with regards to ophthalmic characteristics and systemic diseases, after adjusting for age and sex. RESULTS: PEX was found in 11.9% of the 2261 clinic-visit participants. Participants with PEX, compared with those without, had higher intraocular pressure, larger vertical cup-to-disc ratio, and higher percentage with vertical cup-to-disc ratio asymmetry and optic disc damage. The proportion with glaucoma among pseudoexfoliative participants (15.2%) was higher than that for glaucoma among nonpseudoexfoliative participants (4.7%). After excluding glaucoma participants, the only difference was the 0.6 mm Hg higher intraocular pressure in participants with PEX. Compared with nonpseudoexfoliative eyes, the presence of PEX on iris only or on both iris and lens was associated with higher intraocular pressure, whereas the presence of PEX on lens only was not. PEX was not associated with any systemic disease. CONCLUSIONS: The prevalence of PEX in Greece is relatively high compared with other white populations. PEX was associated with higher intraocular pressure and higher percentage with optic disc damage, secondary to the higher proportion with glaucoma among pseudoexfoliative participants than among nonpseudoexfoliative participants. In nonglaucoma participants, eyes with PEX had only slightly higher intraocular pressure, but this was not observed in eyes with PEX on lens only.

AB - PURPOSE: To report on the prevalence of pseudoexfoliation (PEX) and its association with ophthalmic characteristics and systemic diseases in a well-defined population. METHODS: The Thessaloniki Eye study is a cross-sectional population-based study of chronic eye diseases in Thessaloniki, Greece. Participants with PEX were identified by clinical examination and were compared with those without PEX with regards to ophthalmic characteristics and systemic diseases, after adjusting for age and sex. RESULTS: PEX was found in 11.9% of the 2261 clinic-visit participants. Participants with PEX, compared with those without, had higher intraocular pressure, larger vertical cup-to-disc ratio, and higher percentage with vertical cup-to-disc ratio asymmetry and optic disc damage. The proportion with glaucoma among pseudoexfoliative participants (15.2%) was higher than that for glaucoma among nonpseudoexfoliative participants (4.7%). After excluding glaucoma participants, the only difference was the 0.6 mm Hg higher intraocular pressure in participants with PEX. Compared with nonpseudoexfoliative eyes, the presence of PEX on iris only or on both iris and lens was associated with higher intraocular pressure, whereas the presence of PEX on lens only was not. PEX was not associated with any systemic disease. CONCLUSIONS: The prevalence of PEX in Greece is relatively high compared with other white populations. PEX was associated with higher intraocular pressure and higher percentage with optic disc damage, secondary to the higher proportion with glaucoma among pseudoexfoliative participants than among nonpseudoexfoliative participants. In nonglaucoma participants, eyes with PEX had only slightly higher intraocular pressure, but this was not observed in eyes with PEX on lens only.

KW - glaucoma

KW - intraocular pressure

KW - population-based study

KW - pseudoexfoliation

UR - http://www.scopus.com/inward/record.url?scp=79952694880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952694880&partnerID=8YFLogxK

U2 - 10.1097/IJG.0b013e3181d9d8bd

DO - 10.1097/IJG.0b013e3181d9d8bd

M3 - Article

C2 - 20436360

AN - SCOPUS:79952694880

VL - 20

SP - 160

EP - 166

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

IS - 3

ER -