Characteristics of the Peritumoral Pseudocapsule Vary Predictably With Histologic Subtype of T1 Renal Neoplasms

Joseph M. Jacob, Sean R. Williamson, Dibson D. Gondim, Joshua A. Leese, Colin Terry, David Grignon, Ronald S. Boris

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBJECTIVE: To determine characteristics of the peritumoral pseudocapsule (PC) between renal tumor subtypes.

METHODS: The peritumoral PCs of 160 pT1 renal tumors were examined, including 60 clear cell renal cell carcinomas (RCCs), 50 papillary RCCs, 25 chromophobe RCCs, and 25 oncocytoma. Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by tumor) were analyzed. PC thickness was measured using an ocular micrometer to the nearest 1/10 mm.

RESULTS: A complete PC was found in 77% of clear cell tumors, 74% of papillary, 28% of chromophobe, and 4% of oncocytomas. Tumor PC was present but incomplete in 18% of clear cell, 18% of papillary, 44% of chromophobe, and 56% of oncocytoma. The PC was entirely absent in no clear cell tumors, 6% of papillary, 28% of chromophobe, and 40% of oncocytoma. Mean PC thickness and presence of invasion beyond the PC differed significantly by tumor subtype. Clear cell RCC possessed the thickest PC showing invasion through the capsule in 8% of tumors compared to 30% of papillary tumors. Complete PC invasion was not seen in chromophobe RCC or renal oncocytoma. Oncocytoma and chromophobe RCC characteristically exhibited an incomplete or absent PC.

CONCLUSION: The characteristics of peritumoral PC vary predictably with histologic subtype of renal neoplasms. Clear cell RCC shows the most consistent PC, with a lower rate of invasion beyond it compared to papillary RCC. Chromophobe and oncocytoma characteristically have an incomplete or absent PC.

Original languageEnglish (US)
Pages (from-to)956-961
Number of pages6
JournalUrology
Volume86
Issue number5
DOIs
StatePublished - Nov 1 2015

Fingerprint

Kidney Neoplasms
Oxyphilic Adenoma
Renal Cell Carcinoma
Neoplasms
Kidney
Capsules

ASJC Scopus subject areas

  • Urology

Cite this

Characteristics of the Peritumoral Pseudocapsule Vary Predictably With Histologic Subtype of T1 Renal Neoplasms. / Jacob, Joseph M.; Williamson, Sean R.; Gondim, Dibson D.; Leese, Joshua A.; Terry, Colin; Grignon, David; Boris, Ronald S.

In: Urology, Vol. 86, No. 5, 01.11.2015, p. 956-961.

Research output: Contribution to journalArticle

Jacob, Joseph M. ; Williamson, Sean R. ; Gondim, Dibson D. ; Leese, Joshua A. ; Terry, Colin ; Grignon, David ; Boris, Ronald S. / Characteristics of the Peritumoral Pseudocapsule Vary Predictably With Histologic Subtype of T1 Renal Neoplasms. In: Urology. 2015 ; Vol. 86, No. 5. pp. 956-961.
@article{6d30a13e27b84aca8f0591ada609dab9,
title = "Characteristics of the Peritumoral Pseudocapsule Vary Predictably With Histologic Subtype of T1 Renal Neoplasms",
abstract = "OBJECTIVE: To determine characteristics of the peritumoral pseudocapsule (PC) between renal tumor subtypes.METHODS: The peritumoral PCs of 160 pT1 renal tumors were examined, including 60 clear cell renal cell carcinomas (RCCs), 50 papillary RCCs, 25 chromophobe RCCs, and 25 oncocytoma. Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by tumor) were analyzed. PC thickness was measured using an ocular micrometer to the nearest 1/10 mm.RESULTS: A complete PC was found in 77{\%} of clear cell tumors, 74{\%} of papillary, 28{\%} of chromophobe, and 4{\%} of oncocytomas. Tumor PC was present but incomplete in 18{\%} of clear cell, 18{\%} of papillary, 44{\%} of chromophobe, and 56{\%} of oncocytoma. The PC was entirely absent in no clear cell tumors, 6{\%} of papillary, 28{\%} of chromophobe, and 40{\%} of oncocytoma. Mean PC thickness and presence of invasion beyond the PC differed significantly by tumor subtype. Clear cell RCC possessed the thickest PC showing invasion through the capsule in 8{\%} of tumors compared to 30{\%} of papillary tumors. Complete PC invasion was not seen in chromophobe RCC or renal oncocytoma. Oncocytoma and chromophobe RCC characteristically exhibited an incomplete or absent PC.CONCLUSION: The characteristics of peritumoral PC vary predictably with histologic subtype of renal neoplasms. Clear cell RCC shows the most consistent PC, with a lower rate of invasion beyond it compared to papillary RCC. Chromophobe and oncocytoma characteristically have an incomplete or absent PC.",
author = "Jacob, {Joseph M.} and Williamson, {Sean R.} and Gondim, {Dibson D.} and Leese, {Joshua A.} and Colin Terry and David Grignon and Boris, {Ronald S.}",
year = "2015",
month = "11",
day = "1",
doi = "10.1016/j.urology.2015.06.015",
language = "English (US)",
volume = "86",
pages = "956--961",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Characteristics of the Peritumoral Pseudocapsule Vary Predictably With Histologic Subtype of T1 Renal Neoplasms

AU - Jacob, Joseph M.

AU - Williamson, Sean R.

AU - Gondim, Dibson D.

AU - Leese, Joshua A.

AU - Terry, Colin

AU - Grignon, David

AU - Boris, Ronald S.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - OBJECTIVE: To determine characteristics of the peritumoral pseudocapsule (PC) between renal tumor subtypes.METHODS: The peritumoral PCs of 160 pT1 renal tumors were examined, including 60 clear cell renal cell carcinomas (RCCs), 50 papillary RCCs, 25 chromophobe RCCs, and 25 oncocytoma. Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by tumor) were analyzed. PC thickness was measured using an ocular micrometer to the nearest 1/10 mm.RESULTS: A complete PC was found in 77% of clear cell tumors, 74% of papillary, 28% of chromophobe, and 4% of oncocytomas. Tumor PC was present but incomplete in 18% of clear cell, 18% of papillary, 44% of chromophobe, and 56% of oncocytoma. The PC was entirely absent in no clear cell tumors, 6% of papillary, 28% of chromophobe, and 40% of oncocytoma. Mean PC thickness and presence of invasion beyond the PC differed significantly by tumor subtype. Clear cell RCC possessed the thickest PC showing invasion through the capsule in 8% of tumors compared to 30% of papillary tumors. Complete PC invasion was not seen in chromophobe RCC or renal oncocytoma. Oncocytoma and chromophobe RCC characteristically exhibited an incomplete or absent PC.CONCLUSION: The characteristics of peritumoral PC vary predictably with histologic subtype of renal neoplasms. Clear cell RCC shows the most consistent PC, with a lower rate of invasion beyond it compared to papillary RCC. Chromophobe and oncocytoma characteristically have an incomplete or absent PC.

AB - OBJECTIVE: To determine characteristics of the peritumoral pseudocapsule (PC) between renal tumor subtypes.METHODS: The peritumoral PCs of 160 pT1 renal tumors were examined, including 60 clear cell renal cell carcinomas (RCCs), 50 papillary RCCs, 25 chromophobe RCCs, and 25 oncocytoma. Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by tumor) were analyzed. PC thickness was measured using an ocular micrometer to the nearest 1/10 mm.RESULTS: A complete PC was found in 77% of clear cell tumors, 74% of papillary, 28% of chromophobe, and 4% of oncocytomas. Tumor PC was present but incomplete in 18% of clear cell, 18% of papillary, 44% of chromophobe, and 56% of oncocytoma. The PC was entirely absent in no clear cell tumors, 6% of papillary, 28% of chromophobe, and 40% of oncocytoma. Mean PC thickness and presence of invasion beyond the PC differed significantly by tumor subtype. Clear cell RCC possessed the thickest PC showing invasion through the capsule in 8% of tumors compared to 30% of papillary tumors. Complete PC invasion was not seen in chromophobe RCC or renal oncocytoma. Oncocytoma and chromophobe RCC characteristically exhibited an incomplete or absent PC.CONCLUSION: The characteristics of peritumoral PC vary predictably with histologic subtype of renal neoplasms. Clear cell RCC shows the most consistent PC, with a lower rate of invasion beyond it compared to papillary RCC. Chromophobe and oncocytoma characteristically have an incomplete or absent PC.

UR - http://www.scopus.com/inward/record.url?scp=85027928671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027928671&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2015.06.015

DO - 10.1016/j.urology.2015.06.015

M3 - Article

C2 - 26126697

AN - SCOPUS:85027928671

VL - 86

SP - 956

EP - 961

JO - Urology

JF - Urology

SN - 0090-4295

IS - 5

ER -