Characterization of a cDNA encoding murine coagulation factor VII

Esohe Idusogie, Elliot Rosen, Jie Ping Geng, Peter Carmeliet, Desiré Collen, Francis J. Castellino

Research output: Contribution to journalArticle

20 Scopus citations


The cDNA encoding murine coagulation factor VII (mfVII) was isolated and reconstructed from a h Zap cDNA library generated from murine liver mRNA. The cDNA contains 1903 nucleotides spanning 15 bases upstream of the 5'-translation initiation codon, an open reading frame of 1338 nucleotides, 550 nucleotides downstream of the first stop codon and a 3' poly(A) tail. The translation product is composed of a 41-amino acid signal/propeptide region followed by a 405-residue mature protein. The latter is highly homologous to that of human, rabbit, bovine, Rhesus monkey, and canine fVII. All protein domains of hfVII are strictly conserved in mfVII.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalThrombosis and Haemostasis
Issue number3
StatePublished - Mar 1996

ASJC Scopus subject areas

  • Hematology

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