Characterization of cord blood stem/progenitor cells

Hal Broxmeyer, C. E. Carow

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Based on in vitro studies, umbilical-cord blood has been used clinically to engraft the hematopoietic systems of children. To evaluate the capacity of a single collection of cord blood to engraft an adult, it is important to consider not only the number, but also the quality of stem/progenitor cells in cord blood. We demonstrate that cord blood contains multipotential progenitor cells, possibly subsets of stem cells, that have extensive self- renewal capacity, as estimated by their capacity to form numerous secondary colonies of multiple lineages in secondary replates from single multipotential colonies. This replating capacity is enhanced by a factor or factors, perhaps novel, in cord blood plasma.

Original languageEnglish
Pages (from-to)197-199
Number of pages3
JournalJournal of Hematotherapy
Volume2
Issue number2
StatePublished - 1993

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Fetal Blood
Blood Cells
Stem Cells
Hematopoietic System

ASJC Scopus subject areas

  • Hematology
  • Immunology

Cite this

Characterization of cord blood stem/progenitor cells. / Broxmeyer, Hal; Carow, C. E.

In: Journal of Hematotherapy, Vol. 2, No. 2, 1993, p. 197-199.

Research output: Contribution to journalArticle

Broxmeyer, Hal ; Carow, C. E. / Characterization of cord blood stem/progenitor cells. In: Journal of Hematotherapy. 1993 ; Vol. 2, No. 2. pp. 197-199.
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