Characterization of dicalcium phosphate dihydrate cements prepared using a novel hydroxyapatite-based formulation

Daniel L. Alge, Grace Santa Cruz, W. Scott Goebel, Tien Min Gabriel Chu

Research output: Contribution to journalArticle

13 Scopus citations


Dicalcium phosphate dihydrate (DCPD) cements are typically prepared using β-tricalcium phosphate (β-TCP) as the base component. However, hydroxyapatite (HA) is an interesting alternative because of its potential for reducing cement acidity, as well as modulating cement properties via ionic substitutions. In the present study, we have characterized DCPD cements prepared with a novel formulation based on monocalcium phosphate monohydrate (MCPM) and HA. Cements were prepared using a 4:1 MCPM:HA molar ratio. The reactivity of HA in this system was verified by showing DCPD formation using poorly crystalline HA, as well as highly crystalline HA. Evaluation of cements prepared with poorly crystalline HA revealed that setting occurs rapidly in the MCPM/HA system, and that the use of a setting regulator is necessary to maintain workability of the cement paste. Compressive testing showed that MCPM/HA cements have strengths comparable to what has previously been published for DCPD cements. However, preliminary in vitro analysis of cement degradation revealed that conversion of DCPD to HA may occur much more rapidly in the MCPM/HA system compared to cements prepared with β-TCP. Future studies should investigate this property further, as it could have important implications for the use of HA-based DCPD cement formulations.

Original languageEnglish (US)
Article number025016
JournalBiomedical Materials
Issue number2
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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