Characterization of ischemia-induced loss of epithelial polarity

Bruce Molitoris, Catherine A. Hoilien, Rolf Dahl, Dennis J. Ahnen, Patricia D. Wilson, Jin Kim

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Total renal ischemia for various time intervals (0-50) min) resulted in the rapid and duration-dependent redistribution of polarized membrane lipids and proteins in renal proximal tubule cells. Following only 15 min of ischemia, apical membrane enrichment of NaK-ATPase, normally a basolateral membrane (BLM) enzyme, had increased (1.6±0.6 vs. 2.9±1.2, P

Original languageEnglish (US)
Pages (from-to)233-242
Number of pages10
JournalJournal of Membrane Biology
Volume106
Issue number3
DOIs
StatePublished - Dec 1988
Externally publishedYes

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Ischemia
Proximal Kidney Tubule
Membranes
Membrane Lipids
Adenosine Triphosphatases
Membrane Proteins
Kidney
Enzymes

Keywords

  • ischemia
  • leucine aminopeptidase
  • NaK-ATPase
  • phospholipids
  • surface membrane polarity

ASJC Scopus subject areas

  • Physiology
  • Cell Biology
  • Biophysics

Cite this

Molitoris, B., Hoilien, C. A., Dahl, R., Ahnen, D. J., Wilson, P. D., & Kim, J. (1988). Characterization of ischemia-induced loss of epithelial polarity. Journal of Membrane Biology, 106(3), 233-242. https://doi.org/10.1007/BF01872161

Characterization of ischemia-induced loss of epithelial polarity. / Molitoris, Bruce; Hoilien, Catherine A.; Dahl, Rolf; Ahnen, Dennis J.; Wilson, Patricia D.; Kim, Jin.

In: Journal of Membrane Biology, Vol. 106, No. 3, 12.1988, p. 233-242.

Research output: Contribution to journalArticle

Molitoris, B, Hoilien, CA, Dahl, R, Ahnen, DJ, Wilson, PD & Kim, J 1988, 'Characterization of ischemia-induced loss of epithelial polarity', Journal of Membrane Biology, vol. 106, no. 3, pp. 233-242. https://doi.org/10.1007/BF01872161
Molitoris, Bruce ; Hoilien, Catherine A. ; Dahl, Rolf ; Ahnen, Dennis J. ; Wilson, Patricia D. ; Kim, Jin. / Characterization of ischemia-induced loss of epithelial polarity. In: Journal of Membrane Biology. 1988 ; Vol. 106, No. 3. pp. 233-242.
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