Characterization of size-specific particulate matter emission rates for a simulated medical laser procedure - A pilot study

​Ramon ​Lopez, Steven Lacey, Julia F. Lippert, Li C. Liu, Nurtan A. Esmen, Lorraine M. Conroy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Prior investigation on medical laser interaction with tissue has suggested device operational parameter settings influence laser generated air contaminant emission, but this has not been systematically explored. A laboratory-based simulated medical laser procedure was designed and pilot tested to determine the effect of laser operational parameters on the size-specific mass emission rate of laser generated particulate matter. Porcine tissue was lased in an emission chamber using two medical laser systems (CO2, λ = 10600nm; Ho:YAG, λ = 2100nm) in a fractional factorial study design by varying three operational parameters (beam diameter, pulse repetition frequency, and power) between two levels (high and low) and the resultant plume was measured using two real-time size-selective particle counters. Particle count concentrations were converted to mass emission rates before an analysis of variance was used to determine the influence of operational parameter settings on size-specific mass emission rate. Particle shape and diameter were described for a limited number of samples by collecting particles on polycarbonate filters, and photographed using a scanning electron microscope (SEM) to examine method of particle formation. An increase in power and decrease in beam diameter led to an increase in mass emission for the Ho:YAG laser at all size ranges. For the CO2 laser, emission rates were dependent on particle size and were not statistically significant for particle ranges between 5 and 10 μm. When any parameter level was increased, emission rate of the smallest particle size range also increased. Beam diameter was the most influential variable for both lasers, and the operational parameters tested explained the most variability at the smallest particle size range. Particle shape was variable and some particles observed by SEM were likely created from mechanical methods. This study provides a foundation for future investigations to better estimate size-specific mass emission rates and particle characteristics for additional laser operational parameters in order to estimate occupational exposure, and to inform control strategies.

Original languageEnglish (US)
Pages (from-to)514-524
Number of pages11
JournalAnnals of Occupational Hygiene
Volume59
Issue number4
DOIs
StatePublished - May 1 2015

Fingerprint

Particulate Matter
Lasers
Particle Size
polycarbonate
Gas Lasers
Electrons
Solid-State Lasers
Occupational Exposure
Analysis of Variance
Swine
Air
Equipment and Supplies

Keywords

  • emission rate
  • laser generated particulate matter
  • medical laser
  • particulate matter
  • scanning electron microscopy
  • size-selective air sampling

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Characterization of size-specific particulate matter emission rates for a simulated medical laser procedure - A pilot study. / ​Lopez, ​Ramon; Lacey, Steven; Lippert, Julia F.; Liu, Li C.; Esmen, Nurtan A.; Conroy, Lorraine M.

In: Annals of Occupational Hygiene, Vol. 59, No. 4, 01.05.2015, p. 514-524.

Research output: Contribution to journalArticle

​Lopez, ​Ramon ; Lacey, Steven ; Lippert, Julia F. ; Liu, Li C. ; Esmen, Nurtan A. ; Conroy, Lorraine M. / Characterization of size-specific particulate matter emission rates for a simulated medical laser procedure - A pilot study. In: Annals of Occupational Hygiene. 2015 ; Vol. 59, No. 4. pp. 514-524.
@article{04325605825744bb8ba2b5fd94c5d3e6,
title = "Characterization of size-specific particulate matter emission rates for a simulated medical laser procedure - A pilot study",
abstract = "Prior investigation on medical laser interaction with tissue has suggested device operational parameter settings influence laser generated air contaminant emission, but this has not been systematically explored. A laboratory-based simulated medical laser procedure was designed and pilot tested to determine the effect of laser operational parameters on the size-specific mass emission rate of laser generated particulate matter. Porcine tissue was lased in an emission chamber using two medical laser systems (CO2, λ = 10600nm; Ho:YAG, λ = 2100nm) in a fractional factorial study design by varying three operational parameters (beam diameter, pulse repetition frequency, and power) between two levels (high and low) and the resultant plume was measured using two real-time size-selective particle counters. Particle count concentrations were converted to mass emission rates before an analysis of variance was used to determine the influence of operational parameter settings on size-specific mass emission rate. Particle shape and diameter were described for a limited number of samples by collecting particles on polycarbonate filters, and photographed using a scanning electron microscope (SEM) to examine method of particle formation. An increase in power and decrease in beam diameter led to an increase in mass emission for the Ho:YAG laser at all size ranges. For the CO2 laser, emission rates were dependent on particle size and were not statistically significant for particle ranges between 5 and 10 μm. When any parameter level was increased, emission rate of the smallest particle size range also increased. Beam diameter was the most influential variable for both lasers, and the operational parameters tested explained the most variability at the smallest particle size range. Particle shape was variable and some particles observed by SEM were likely created from mechanical methods. This study provides a foundation for future investigations to better estimate size-specific mass emission rates and particle characteristics for additional laser operational parameters in order to estimate occupational exposure, and to inform control strategies.",
keywords = "emission rate, laser generated particulate matter, medical laser, particulate matter, scanning electron microscopy, size-selective air sampling",
author = "​Ramon ​Lopez and Steven Lacey and Lippert, {Julia F.} and Liu, {Li C.} and Esmen, {Nurtan A.} and Conroy, {Lorraine M.}",
year = "2015",
month = "5",
day = "1",
doi = "10.1093/annhyg/meu115",
language = "English (US)",
volume = "59",
pages = "514--524",
journal = "Annals of Work Exposures and Health",
issn = "2398-7308",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Characterization of size-specific particulate matter emission rates for a simulated medical laser procedure - A pilot study

AU - ​Lopez, ​Ramon

AU - Lacey, Steven

AU - Lippert, Julia F.

AU - Liu, Li C.

AU - Esmen, Nurtan A.

AU - Conroy, Lorraine M.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Prior investigation on medical laser interaction with tissue has suggested device operational parameter settings influence laser generated air contaminant emission, but this has not been systematically explored. A laboratory-based simulated medical laser procedure was designed and pilot tested to determine the effect of laser operational parameters on the size-specific mass emission rate of laser generated particulate matter. Porcine tissue was lased in an emission chamber using two medical laser systems (CO2, λ = 10600nm; Ho:YAG, λ = 2100nm) in a fractional factorial study design by varying three operational parameters (beam diameter, pulse repetition frequency, and power) between two levels (high and low) and the resultant plume was measured using two real-time size-selective particle counters. Particle count concentrations were converted to mass emission rates before an analysis of variance was used to determine the influence of operational parameter settings on size-specific mass emission rate. Particle shape and diameter were described for a limited number of samples by collecting particles on polycarbonate filters, and photographed using a scanning electron microscope (SEM) to examine method of particle formation. An increase in power and decrease in beam diameter led to an increase in mass emission for the Ho:YAG laser at all size ranges. For the CO2 laser, emission rates were dependent on particle size and were not statistically significant for particle ranges between 5 and 10 μm. When any parameter level was increased, emission rate of the smallest particle size range also increased. Beam diameter was the most influential variable for both lasers, and the operational parameters tested explained the most variability at the smallest particle size range. Particle shape was variable and some particles observed by SEM were likely created from mechanical methods. This study provides a foundation for future investigations to better estimate size-specific mass emission rates and particle characteristics for additional laser operational parameters in order to estimate occupational exposure, and to inform control strategies.

AB - Prior investigation on medical laser interaction with tissue has suggested device operational parameter settings influence laser generated air contaminant emission, but this has not been systematically explored. A laboratory-based simulated medical laser procedure was designed and pilot tested to determine the effect of laser operational parameters on the size-specific mass emission rate of laser generated particulate matter. Porcine tissue was lased in an emission chamber using two medical laser systems (CO2, λ = 10600nm; Ho:YAG, λ = 2100nm) in a fractional factorial study design by varying three operational parameters (beam diameter, pulse repetition frequency, and power) between two levels (high and low) and the resultant plume was measured using two real-time size-selective particle counters. Particle count concentrations were converted to mass emission rates before an analysis of variance was used to determine the influence of operational parameter settings on size-specific mass emission rate. Particle shape and diameter were described for a limited number of samples by collecting particles on polycarbonate filters, and photographed using a scanning electron microscope (SEM) to examine method of particle formation. An increase in power and decrease in beam diameter led to an increase in mass emission for the Ho:YAG laser at all size ranges. For the CO2 laser, emission rates were dependent on particle size and were not statistically significant for particle ranges between 5 and 10 μm. When any parameter level was increased, emission rate of the smallest particle size range also increased. Beam diameter was the most influential variable for both lasers, and the operational parameters tested explained the most variability at the smallest particle size range. Particle shape was variable and some particles observed by SEM were likely created from mechanical methods. This study provides a foundation for future investigations to better estimate size-specific mass emission rates and particle characteristics for additional laser operational parameters in order to estimate occupational exposure, and to inform control strategies.

KW - emission rate

KW - laser generated particulate matter

KW - medical laser

KW - particulate matter

KW - scanning electron microscopy

KW - size-selective air sampling

UR - http://www.scopus.com/inward/record.url?scp=84929463553&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929463553&partnerID=8YFLogxK

U2 - 10.1093/annhyg/meu115

DO - 10.1093/annhyg/meu115

M3 - Article

VL - 59

SP - 514

EP - 524

JO - Annals of Work Exposures and Health

JF - Annals of Work Exposures and Health

SN - 2398-7308

IS - 4

ER -