Characterization of small intestinal submucosa regenerated canine detrusor: Assessment of reinnervation, in vitro compliance and contractility

Bradley P. Kropp, Barry D. Sawyer, Harlon E. Shannon, Marian K. Rippy, Stephen F. Badylak, Mark C. Adams, Michael A. Keating, Richard C. Rink, Karl B. Thor

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

Purpose: We characterized small intestinal submucosa regenerated canine bladder. Materials and Methods: We subjected 15-month small intestinal submucosa regenerated canine bladder strips to in vitro muscle bath compliance, contractility testing and immunohistochemical staining. Results: Compliance studies demonstrated no significant difference between small intestinal submucosa regenerated and control bladders, which were 30-fold more compliant than native small intestinal submucosal graft material. Contractility studies demonstrated contractile responses and innervation similar to those of normal canine bladder. Afferent nerves were demonstrated through immunohistochemical techniques. Conclusions: These characteristics further support the regenerative capacity of small intestinal submucosa and its potential use as a bladder augmentation material.

Original languageEnglish (US)
Pages (from-to)599-607
Number of pages9
JournalJournal of Urology
Volume156
Issue number2 SUPPL. 1
DOIs
StatePublished - Aug 1996

Keywords

  • Biocompatible materials
  • Bladder
  • Innervation
  • Muscle, smooth
  • Regeneration

ASJC Scopus subject areas

  • Urology

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    Kropp, B. P., Sawyer, B. D., Shannon, H. E., Rippy, M. K., Badylak, S. F., Adams, M. C., Keating, M. A., Rink, R. C., & Thor, K. B. (1996). Characterization of small intestinal submucosa regenerated canine detrusor: Assessment of reinnervation, in vitro compliance and contractility. Journal of Urology, 156(2 SUPPL. 1), 599-607. https://doi.org/10.1016/S0022-5347(01)65761-6