We have characterized a monoclonal antibody (AT389), produced by immunization of mice with 4‐day‐old avian Concanavalin A blasts, which recognizes a 38 40 kDa homodimer present on the surface of all chicken T cells. AT389 increased the spontaneous and IL‐2‐driven proliferation of 3‐day‐old T‐cell blasts. This antibody, in synergy with IL‐2, increased cellular proliferation and cell survival of T‐cell blasts over time. Together, these data suggest that AT389 recognizes a surface protein on avian T cells which may be related to known stimulatory surface markers on mammalian T cells.
|Original language||English (US)|
|Number of pages||5|
|Journal||Scandinavian Journal of Immunology|
|State||Published - Aug 1993|
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