Characterization of Stimulatory Surface Molecule Expression on Avian T Cells

M. H. KAPLAN, S. ALHASAN, A. ROSENSPIRE, R. S. SUNDICK

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We have characterized a monoclonal antibody (AT389), produced by immunization of mice with 4‐day‐old avian Concanavalin A blasts, which recognizes a 38 40 kDa homodimer present on the surface of all chicken T cells. AT389 increased the spontaneous and IL‐2‐driven proliferation of 3‐day‐old T‐cell blasts. This antibody, in synergy with IL‐2, increased cellular proliferation and cell survival of T‐cell blasts over time. Together, these data suggest that AT389 recognizes a surface protein on avian T cells which may be related to known stimulatory surface markers on mammalian T cells.

Original languageEnglish (US)
Pages (from-to)153-157
Number of pages5
JournalScandinavian Journal of Immunology
Volume38
Issue number2
DOIs
StatePublished - Aug 1993
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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