Characterization of stimulatory surface molecule expression on avian T cells

Mark Kaplan, S. Alhasan, A. Rosenspire, R. S. Sundick

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have characterized a monoclonal antibody (AT389), produced by immunization of mice with 4-day-old avian Concanavalin A blasts, which recognizes a 38-40 kDa homodimer present on the surface of all chicken T cells. AT389 increased the spontaneous and IL-2-driven proliferation of 3-day-old T-cell blasts. This antibody, in synergy with IL-2, increased cellular proliferation and cell survival of T-cell blasts over time. Together, these data suggest that AT389 recognizes a surface protein on avian T cells which may be related to known stimulatory surface markers on mammalian T cells.

Original languageEnglish (US)
Pages (from-to)153-157
Number of pages5
JournalScandinavian Journal of Immunology
Volume38
Issue number2
StatePublished - 1993
Externally publishedYes

Fingerprint

T-Lymphocytes
Interleukin-2
Concanavalin A
Chickens
Immunization
Cell Survival
Membrane Proteins
Monoclonal Antibodies
Cell Proliferation
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Characterization of stimulatory surface molecule expression on avian T cells. / Kaplan, Mark; Alhasan, S.; Rosenspire, A.; Sundick, R. S.

In: Scandinavian Journal of Immunology, Vol. 38, No. 2, 1993, p. 153-157.

Research output: Contribution to journalArticle

Kaplan, M, Alhasan, S, Rosenspire, A & Sundick, RS 1993, 'Characterization of stimulatory surface molecule expression on avian T cells', Scandinavian Journal of Immunology, vol. 38, no. 2, pp. 153-157.
Kaplan, Mark ; Alhasan, S. ; Rosenspire, A. ; Sundick, R. S. / Characterization of stimulatory surface molecule expression on avian T cells. In: Scandinavian Journal of Immunology. 1993 ; Vol. 38, No. 2. pp. 153-157.
@article{2b6beeb8932b4abfad0823f57ed2b289,
title = "Characterization of stimulatory surface molecule expression on avian T cells",
abstract = "We have characterized a monoclonal antibody (AT389), produced by immunization of mice with 4-day-old avian Concanavalin A blasts, which recognizes a 38-40 kDa homodimer present on the surface of all chicken T cells. AT389 increased the spontaneous and IL-2-driven proliferation of 3-day-old T-cell blasts. This antibody, in synergy with IL-2, increased cellular proliferation and cell survival of T-cell blasts over time. Together, these data suggest that AT389 recognizes a surface protein on avian T cells which may be related to known stimulatory surface markers on mammalian T cells.",
author = "Mark Kaplan and S. Alhasan and A. Rosenspire and Sundick, {R. S.}",
year = "1993",
language = "English (US)",
volume = "38",
pages = "153--157",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Characterization of stimulatory surface molecule expression on avian T cells

AU - Kaplan, Mark

AU - Alhasan, S.

AU - Rosenspire, A.

AU - Sundick, R. S.

PY - 1993

Y1 - 1993

N2 - We have characterized a monoclonal antibody (AT389), produced by immunization of mice with 4-day-old avian Concanavalin A blasts, which recognizes a 38-40 kDa homodimer present on the surface of all chicken T cells. AT389 increased the spontaneous and IL-2-driven proliferation of 3-day-old T-cell blasts. This antibody, in synergy with IL-2, increased cellular proliferation and cell survival of T-cell blasts over time. Together, these data suggest that AT389 recognizes a surface protein on avian T cells which may be related to known stimulatory surface markers on mammalian T cells.

AB - We have characterized a monoclonal antibody (AT389), produced by immunization of mice with 4-day-old avian Concanavalin A blasts, which recognizes a 38-40 kDa homodimer present on the surface of all chicken T cells. AT389 increased the spontaneous and IL-2-driven proliferation of 3-day-old T-cell blasts. This antibody, in synergy with IL-2, increased cellular proliferation and cell survival of T-cell blasts over time. Together, these data suggest that AT389 recognizes a surface protein on avian T cells which may be related to known stimulatory surface markers on mammalian T cells.

UR - http://www.scopus.com/inward/record.url?scp=0027319270&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027319270&partnerID=8YFLogxK

M3 - Article

VL - 38

SP - 153

EP - 157

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 2

ER -