Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies

L. M. Reyes, R. J. Blosser, R. F. Smith, A. C. Miner, L. L. Paris, R. L. Blankenship, Matthew F. Tector, A. J. Tector

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have characterized swine leucocyte antigen (SLA) classes I and II molecules of a domestic pig as a model for use in our xenotransplant program. Molecular characterization of the SLA classes I and II genes is critical to understanding the adaptive immune responses between swine and humans in the event of xenotransplantation. Seven swine leucocyte antigen genes (SLA-1, SLA-2, SLA-3, DQB1, DRB1, DQA and DRA) were analyzed and 15 alleles were identified. A novel DRA*w04re01 is reported for this limited polymorphic class II gene. The heterozygous haplotypes, Hp-32.0/35.0 and Hp-0.13/0.23 were deduced for our IU-pig model, for SLA classes I and II regions, respectively.

Original languageEnglish
Pages (from-to)484-488
Number of pages5
JournalTissue Antigens
Volume84
Issue number5
DOIs
StatePublished - Nov 1 2014

Fingerprint

Swine
Alleles
MHC Class II Genes
MHC Class I Genes
Sus scrofa
Heterologous Transplantation
Adaptive Immunity
swine leukocyte antigen
Haplotypes
Genes

Keywords

  • Genotyping
  • Haplotypes
  • Polymorphism
  • Sus scrofa
  • Swine leucocyte antigen
  • Xenotransplantation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Genetics
  • Medicine(all)

Cite this

Reyes, L. M., Blosser, R. J., Smith, R. F., Miner, A. C., Paris, L. L., Blankenship, R. L., ... Tector, A. J. (2014). Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies. Tissue Antigens, 84(5), 484-488. https://doi.org/10.1111/tan.12430

Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies. / Reyes, L. M.; Blosser, R. J.; Smith, R. F.; Miner, A. C.; Paris, L. L.; Blankenship, R. L.; Tector, Matthew F.; Tector, A. J.

In: Tissue Antigens, Vol. 84, No. 5, 01.11.2014, p. 484-488.

Research output: Contribution to journalArticle

Reyes, LM, Blosser, RJ, Smith, RF, Miner, AC, Paris, LL, Blankenship, RL, Tector, MF & Tector, AJ 2014, 'Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies', Tissue Antigens, vol. 84, no. 5, pp. 484-488. https://doi.org/10.1111/tan.12430
Reyes LM, Blosser RJ, Smith RF, Miner AC, Paris LL, Blankenship RL et al. Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies. Tissue Antigens. 2014 Nov 1;84(5):484-488. https://doi.org/10.1111/tan.12430
Reyes, L. M. ; Blosser, R. J. ; Smith, R. F. ; Miner, A. C. ; Paris, L. L. ; Blankenship, R. L. ; Tector, Matthew F. ; Tector, A. J. / Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies. In: Tissue Antigens. 2014 ; Vol. 84, No. 5. pp. 484-488.
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