Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies

L. M. Reyes, R. J. Blosser, R. F. Smith, A. C. Miner, L. L. Paris, R. L. Blankenship, Matthew F. Tector, A. J. Tector

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We have characterized swine leucocyte antigen (SLA) classes I and II molecules of a domestic pig as a model for use in our xenotransplant program. Molecular characterization of the SLA classes I and II genes is critical to understanding the adaptive immune responses between swine and humans in the event of xenotransplantation. Seven swine leucocyte antigen genes (SLA-1, SLA-2, SLA-3, DQB1, DRB1, DQA and DRA) were analyzed and 15 alleles were identified. A novel DRA*w04re01 is reported for this limited polymorphic class II gene. The heterozygous haplotypes, Hp-32.0/35.0 and Hp-0.13/0.23 were deduced for our IU-pig model, for SLA classes I and II regions, respectively.

Original languageEnglish (US)
Pages (from-to)484-488
Number of pages5
JournalTissue Antigens
Volume84
Issue number5
DOIs
StatePublished - Nov 1 2014

Keywords

  • Genotyping
  • Haplotypes
  • Polymorphism
  • Sus scrofa
  • Swine leucocyte antigen
  • Xenotransplantation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Genetics
  • Medicine(all)

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    Reyes, L. M., Blosser, R. J., Smith, R. F., Miner, A. C., Paris, L. L., Blankenship, R. L., Tector, M. F., & Tector, A. J. (2014). Characterization of swine leucocyte antigen alleles in a crossbred pig to be used in xenotransplant studies. Tissue Antigens, 84(5), 484-488. https://doi.org/10.1111/tan.12430