Characterization of the serotype e polysaccharide antigen of Streptococcus mutans

David G. Pritchard, Richard Gregory, Suzanne M. Michalek, Jerry R. McGhee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The structure of the Streptococcus mutans serotype e polysaccharide was studied in order to determine the chemical basis of the immunological cross-reactions observed between it and the streptococcal group E polysaccharide. The chemical structure was established using methylation analysis, periodate oxidation, partial methanolysis and 13C NMR spectroscopy. The polysaccharide was found to consist of a polyrhamnose backbone of alternating 2- and 3-linked α-l-rhamnose units and sidechain β-d-glucosyl units linked to the 2-position of rhamnose units in the backbone. This structure of the oligosaccharide repeating unit of the S. mutans serotype e polysaccharide was identical to that of the group-specific polysaccharide of group E Streptococcus. Possible explanations for the previously reported differences in these two polysaccharides are discussed.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalMolecular Immunology
Volume23
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Streptococcus mutans
Hepatitis B e Antigens
Polysaccharides
Rhamnose
Cross Reactions
Streptococcus
Oligosaccharides
Methylation
Serogroup
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Characterization of the serotype e polysaccharide antigen of Streptococcus mutans. / Pritchard, David G.; Gregory, Richard; Michalek, Suzanne M.; McGhee, Jerry R.

In: Molecular Immunology, Vol. 23, No. 2, 1986, p. 141-145.

Research output: Contribution to journalArticle

Pritchard, David G. ; Gregory, Richard ; Michalek, Suzanne M. ; McGhee, Jerry R. / Characterization of the serotype e polysaccharide antigen of Streptococcus mutans. In: Molecular Immunology. 1986 ; Vol. 23, No. 2. pp. 141-145.
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