Characterization of the serotype e polysaccharide antigen of Streptococcus mutans

David G. Pritchard, Richard L. Gregory, Suzanne M. Michalek, Jerry R. McGhee

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9 Scopus citations


The structure of the Streptococcus mutans serotype e polysaccharide was studied in order to determine the chemical basis of the immunological cross-reactions observed between it and the streptococcal group E polysaccharide. The chemical structure was established using methylation analysis, periodate oxidation, partial methanolysis and 13C NMR spectroscopy. The polysaccharide was found to consist of a polyrhamnose backbone of alternating 2- and 3-linked α-l-rhamnose units and sidechain β-d-glucosyl units linked to the 2-position of rhamnose units in the backbone. This structure of the oligosaccharide repeating unit of the S. mutans serotype e polysaccharide was identical to that of the group-specific polysaccharide of group E Streptococcus. Possible explanations for the previously reported differences in these two polysaccharides are discussed.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalMolecular Immunology
Issue number2
StatePublished - Feb 1986
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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