Characterizing the roles of long non-coding RNA in rat alcohol preference

Ao Zhou, Yadong Wang, Yunlong Liu, Weixing Feng, Howard Edenberg

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Alcohol is one of the major threats to health in United States. With the emerging of next-generation sequencing technology, the association between alcohol preference and the variants and expression of genes has been investigated. However, the roles of long non-coding RNAs (lncRNA) in alcohol preference remains unclear. In this study, we identified 37 novel lncRNAs that differentially expressed across alcohol preferring (P) and non-preferring (NP) rats. The functional study on these lncRNAs demonstrates that they are associated with gene regulation, as well as neural functions. This suggests that these lncRNAs may contribute to the alcohol preference behaviors.

Original languageEnglish (US)
Title of host publicationProceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages167-173
Number of pages7
ISBN (Electronic)9781509016105
DOIs
StatePublished - Jan 17 2017
Event2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 - Shenzhen, China
Duration: Dec 15 2016Dec 18 2016

Other

Other2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
CountryChina
CityShenzhen
Period12/15/1612/18/16

Keywords

  • Alcohol preference
  • Long non-coding RNA
  • Next generation sequencing

ASJC Scopus subject areas

  • Genetics
  • Medicine (miscellaneous)
  • Genetics(clinical)
  • Biochemistry, medical
  • Biochemistry
  • Molecular Medicine
  • Health Informatics

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  • Cite this

    Zhou, A., Wang, Y., Liu, Y., Feng, W., & Edenberg, H. (2017). Characterizing the roles of long non-coding RNA in rat alcohol preference. In Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 (pp. 167-173). [7822513] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2016.7822513