CHD associated with syndromic diagnoses: Peri-operative risk factors and early outcomes

Benjamin J. Landis, David S. Cooper, Robert B. Hinton

Research output: Contribution to journalReview article

18 Scopus citations


CHD is frequently associated with a genetic syndrome. These syndromes often present specific cardiovascular and non-cardiovascular co-morbidities that confer significant peri-operative risks affecting multiple organ systems. Although surgical outcomes have improved over time, these co-morbidities continue to contribute substantially to poor peri-operative mortality and morbidity outcomes. Peri-operative morbidity may have long-standing ramifications on neurodevelopment and overall health. Recognising the cardiovascular and non-cardiovascular risks associated with specific syndromic diagnoses will facilitate expectant management, early detection of clinical problems, and improved outcomes - for example, the development of syndrome-based protocols for peri-operative evaluation and prophylactic actions may improve outcomes for the more frequently encountered syndromes such as 22q11 deletion syndrome.

Original languageEnglish (US)
Pages (from-to)30-52
Number of pages23
JournalCardiology in the Young
Issue number1
StatePublished - Dec 22 2014


  • CHD
  • genetic
  • syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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