Chemical ablation of ventricular tachycardia in the dog

Donald A. Chilson, Pamela S. Peigh, Yousuf Mahomed, Bruce F. Waller, Douglas P. Zipes

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Sustained ventricular tachycardia was induced in dogs following occlusion-reperfusion of the left anterior descending coronary artery. While dogs were supported by cardiopulmonary bypass, the left ventricle was opened and the endocardium was mapped during electrically induced ventricular tachycardia to determine the earliest site of ventricular activation. Phenol (carbolic acid) application at that site necrosed myocardium to a depth of 1 to 3 mm and prevented electrical reinduction of ventricular tachycardia in 9 of 15 dogs. These data suggest that chemical ablation may be used as an alternate means to destroy areas of myocardium involved in the genesis or maintenance of ventricular tachycardia, particularly if these areas cannot be resected surgically because of their size or location.

Original languageEnglish
Pages (from-to)1113-1118
Number of pages6
JournalAmerican Heart Journal
Volume111
Issue number6
DOIs
StatePublished - 1986

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Ventricular Tachycardia
Dogs
Phenol
Myocardium
Endocardium
Cardiopulmonary Bypass
Reperfusion
Heart Ventricles
Coronary Vessels
Maintenance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chilson, D. A., Peigh, P. S., Mahomed, Y., Waller, B. F., & Zipes, D. P. (1986). Chemical ablation of ventricular tachycardia in the dog. American Heart Journal, 111(6), 1113-1118. https://doi.org/10.1016/0002-8703(86)90014-1

Chemical ablation of ventricular tachycardia in the dog. / Chilson, Donald A.; Peigh, Pamela S.; Mahomed, Yousuf; Waller, Bruce F.; Zipes, Douglas P.

In: American Heart Journal, Vol. 111, No. 6, 1986, p. 1113-1118.

Research output: Contribution to journalArticle

Chilson, DA, Peigh, PS, Mahomed, Y, Waller, BF & Zipes, DP 1986, 'Chemical ablation of ventricular tachycardia in the dog', American Heart Journal, vol. 111, no. 6, pp. 1113-1118. https://doi.org/10.1016/0002-8703(86)90014-1
Chilson DA, Peigh PS, Mahomed Y, Waller BF, Zipes DP. Chemical ablation of ventricular tachycardia in the dog. American Heart Journal. 1986;111(6):1113-1118. https://doi.org/10.1016/0002-8703(86)90014-1
Chilson, Donald A. ; Peigh, Pamela S. ; Mahomed, Yousuf ; Waller, Bruce F. ; Zipes, Douglas P. / Chemical ablation of ventricular tachycardia in the dog. In: American Heart Journal. 1986 ; Vol. 111, No. 6. pp. 1113-1118.
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