Chemokine-mobilized adult stem cells; defining a better hematopoietic graft

Louis Pelus, S. Fukuda

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Stem cell research is currently focused on totipotent stem cells and their therapeutic potential, however adult stem cells, while restricted to differentiation within their tissue or origin, also have therapeutic utility. Transplantation with bone marrow hematopoietic stem cells (HSC) has been used for curative therapy for decades. More recently, alternative sources of HSC, particularly those induced to exit marrow or mobilize to peripheral blood by G-CSF, have become the most widely used hematopoietic graft and show significant superiority to marrow HSC. The chemokine/chemokine receptor axis also mobilizes HSC that occurs more rapidly than with G-CSF. In mice, the HSC and progenitor cells (HPC) mobilized by the CXCR2 receptor agonist GROβ can be harvested within minutes of administration and show significantly lower levels of apoptosis, enhanced homing to marrow, expression of more activated integrin receptors and superior repopulation kinetics and more competitive engraftment than the equivalent cells mobilized by G-CSF. These characteristics suggest that chemokine axis-mobilized HSC represent a population of adult stem cells distinct from those mobilized by G-CSF, with superior therapeutic potential. It remains to be determined if the chemokine mobilization axis can be harnessed to mobilize other populations of unique adult stem cells with clinical utility.

Original languageEnglish
Pages (from-to)466-473
Number of pages8
JournalLeukemia
Volume22
Issue number3
DOIs
StatePublished - Mar 2008

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Adult Stem Cells
Hematopoietic Stem Cells
Chemokines
Granulocyte Colony-Stimulating Factor
Transplants
Bone Marrow
Totipotent Stem Cells
Interleukin-8B Receptors
Stem Cell Research
Chemokine Receptors
Therapeutics
Bone Marrow Transplantation
Integrins
Population
Stem Cells
Apoptosis

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

Chemokine-mobilized adult stem cells; defining a better hematopoietic graft. / Pelus, Louis; Fukuda, S.

In: Leukemia, Vol. 22, No. 3, 03.2008, p. 466-473.

Research output: Contribution to journalArticle

Pelus, Louis ; Fukuda, S. / Chemokine-mobilized adult stem cells; defining a better hematopoietic graft. In: Leukemia. 2008 ; Vol. 22, No. 3. pp. 466-473.
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