Chemokine signaling and the management of neuropathic pain

Fletcher White, Polina Feldman, Richard J. Miller

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Chemokines and chemokine receptors are widely expressed in the nervous system, where they play roles in the regulation of stem cell migration, axonal path finding, and neurotransmission. Chemokine signaling is also of key importance in the regulation of neuroinflammatory responses. The expression of the chemokine monocyte chemoattractant protein 1 (MCP1) and its receptor (CCR2) is upregulated by dorsal root ganglia neurons in rodent models of neuropathic pain. MCP1 increases the excitability of nociceptive neurons after a peripheral nerve injury, and disruption of MCP1 signaling blocks the development of neuropathic pain. In the spinal cord, microglial cells expressing CCR2 are thought to play an active role in the initiation and maintenance of pain hypersensitivity, and MCP1 may also alter the excitability of spinal neurons in some cases. Other predominant sites of CCR2 activation are found in the peripheral nervous system, thereby explaining, at least in some circumstances, the rapid anti-nociceptive effects of peripherally administered CCR2 antagonists. In this article we discuss the relative roles of CCR2 activation in the peripheral and central nervous systems in relation to the phenomenon of neuropathic pain.

Original languageEnglish (US)
Pages (from-to)188-195
Number of pages8
JournalMolecular Interventions
Volume9
Issue number4
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

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Chemokine CCL2
Neuralgia
Chemokines
Peripheral Nervous System
CCR2 Receptors
Neurons
Peripheral Nerve Injuries
Nociceptors
Chemokine Receptors
Spinal Ganglia
Synaptic Transmission
Nervous System
Cell Movement
Rodentia
Spinal Cord
Hypersensitivity
Stem Cells
Central Nervous System
Maintenance
Pain

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Chemokine signaling and the management of neuropathic pain. / White, Fletcher; Feldman, Polina; Miller, Richard J.

In: Molecular Interventions, Vol. 9, No. 4, 01.08.2009, p. 188-195.

Research output: Contribution to journalArticle

White, Fletcher ; Feldman, Polina ; Miller, Richard J. / Chemokine signaling and the management of neuropathic pain. In: Molecular Interventions. 2009 ; Vol. 9, No. 4. pp. 188-195.
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