Chemokines as pain mediators and modulators

Fletcher A. White, Natalie M. Wilson

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

Purpose of review: Chemokines are central to the innate immune response following tissue damage, injury and some diseases. The function of chemokines in nervous system autoimmune diseases has been long recognized. There is also growing evidence that diseaseassociated or injury-induced functional expression of chemokines/receptors in both neural and nonneural elements of the peripheral nervous system play crucial roles in the pathophysiology of chronic pain. Recent findings: Chemokine involvement in neuropathic pain processing has recently been established in animal models. Evidence of chemokine contribution to chronic pain includes the upregulation of monocyte chemoattractant protein-1 (MCP-1/CCL2) and its respective receptor, CCR2, in many subpopulations of sensory neurons. Activation of CCR2 by MCP-1 elicits membrane depolarization, triggers action potentials and sensitizes nociceptors via transactivation of transient receptor potential channels TRPA1 and TRPV1. Increased signaling by stromal-derived factor-1 (SDF-1/CXCL12) and its receptor, CXCR4, has been shown to contribute to chronic pain behavior. The use of specific chemokine receptor antagonists for CCR2 and CXCR4 successfully reverses nociceptive pain behavior. Summary: Our results suggest that specific chemokines/receptors are upregulated by sensory neurons following peripheral nerve injury and appear to participate in neural signal processing leading to chronic pain states. Taken together, chemokines and their receptors are potential targets for development of novel therapeutics.

Original languageEnglish (US)
Pages (from-to)580-585
Number of pages6
JournalCurrent Opinion in Anaesthesiology
Volume21
Issue number5
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

Keywords

  • Chemokines
  • Models
  • Pain
  • Receptors

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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