Chemokines, chemokine receptors and hematopoiesis

Byung S. Youn, Charlie Mantel, Hal E. Broxmeyer

Research output: Contribution to journalReview article

99 Citations (Scopus)

Abstract

Hematopoiesis during steady state conditions is regulated and finely tuned by a network of cytokines and their effects on hematopoietic stem and progenitor cells and on accessory cells that influence the stem and progenitor cells. Amongst the numerous cytokines implicated in this regulation are members of the CC, CXC and C family of chemokines. Twenty-five chemokine members have been demonstrated to have the capacity to suppress the proliferation of myeloid progenitor cells. Three chemokines have been implicated in the chemotaxis of these stem and progenitor cells, and one has been linked to their survival after growth factor withdrawal. This review focuses on the proliferation-suppressing, chemotaxis-induced, and cell survival effects of different chemokine family members on myeloid progenitor cells. This is placed in the context of what we know and don't know about the intracellular signaling events mediating these effects. This information and what is yet to be learned in this area could have important clinical implications for treatment of disease.

Original languageEnglish (US)
Pages (from-to)150-174
Number of pages25
JournalImmunological Reviews
Volume177
DOIs
StatePublished - Jan 1 2000

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Chemokine Receptors
Hematopoiesis
Chemokines
Stem Cells
Myeloid Progenitor Cells
Chemotaxis
Hematopoietic Stem Cells
C Chemokines
Cytokines
Cell Survival
Intercellular Signaling Peptides and Proteins
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Chemokines, chemokine receptors and hematopoiesis. / Youn, Byung S.; Mantel, Charlie; Broxmeyer, Hal E.

In: Immunological Reviews, Vol. 177, 01.01.2000, p. 150-174.

Research output: Contribution to journalReview article

Youn, Byung S. ; Mantel, Charlie ; Broxmeyer, Hal E. / Chemokines, chemokine receptors and hematopoiesis. In: Immunological Reviews. 2000 ; Vol. 177. pp. 150-174.
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