Chemokines in multiple myeloma

Rohit Aggarwal, Irene M. Ghobrial, G. David Roodman

Research output: Contribution to journalReview article

106 Scopus citations

Abstract

Objective: In this article we focus on the role that chemokines and chemokine receptors play in the pathogenesis of multiple myeloma and the associated bone destructive process, and consider their utility as novel therapeutic targets for treating this devastating disease. Methods: Current research on the role that chemokine and chemokine receptors play in the pathogenesis of myeloma is reviewed. Results: The chemokines, MIP-1α, MCP-1, IL-8, and SDF-1, and their receptors play important roles in homing of MM cells, tumor growth, and bone destruction in myeloma. They are attractive therapeutic targets for treating myeloma patients. Conclusion: Addition of chemokine antagonists to current treatment regimens for myeloma should result in better therapeutic responses because of the loss of both the protective effect of the marrow microenvironment on the MM cells and the induction of osteoclast activity.

Original languageEnglish (US)
Pages (from-to)1289-1295
Number of pages7
JournalExperimental Hematology
Volume34
Issue number10
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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