Chemokines in multiple myeloma

Rohit Aggarwal, Irene M. Ghobrial, G. David Roodman

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Objective: In this article we focus on the role that chemokines and chemokine receptors play in the pathogenesis of multiple myeloma and the associated bone destructive process, and consider their utility as novel therapeutic targets for treating this devastating disease. Methods: Current research on the role that chemokine and chemokine receptors play in the pathogenesis of myeloma is reviewed. Results: The chemokines, MIP-1α, MCP-1, IL-8, and SDF-1, and their receptors play important roles in homing of MM cells, tumor growth, and bone destruction in myeloma. They are attractive therapeutic targets for treating myeloma patients. Conclusion: Addition of chemokine antagonists to current treatment regimens for myeloma should result in better therapeutic responses because of the loss of both the protective effect of the marrow microenvironment on the MM cells and the induction of osteoclast activity.

Original languageEnglish (US)
Pages (from-to)1289-1295
Number of pages7
JournalExperimental Hematology
Volume34
Issue number10
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

Multiple Myeloma
Chemokines
Chemokine Receptors
Bone Development
Osteoclasts
Therapeutics
Interleukin-8
Bone Marrow
Bone and Bones
Research
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Cite this

Chemokines in multiple myeloma. / Aggarwal, Rohit; Ghobrial, Irene M.; Roodman, G. David.

In: Experimental Hematology, Vol. 34, No. 10, 10.2006, p. 1289-1295.

Research output: Contribution to journalArticle

Aggarwal, Rohit ; Ghobrial, Irene M. ; Roodman, G. David. / Chemokines in multiple myeloma. In: Experimental Hematology. 2006 ; Vol. 34, No. 10. pp. 1289-1295.
@article{b6d79035818141878973ddbd2e7fa47f,
title = "Chemokines in multiple myeloma",
abstract = "Objective: In this article we focus on the role that chemokines and chemokine receptors play in the pathogenesis of multiple myeloma and the associated bone destructive process, and consider their utility as novel therapeutic targets for treating this devastating disease. Methods: Current research on the role that chemokine and chemokine receptors play in the pathogenesis of myeloma is reviewed. Results: The chemokines, MIP-1α, MCP-1, IL-8, and SDF-1, and their receptors play important roles in homing of MM cells, tumor growth, and bone destruction in myeloma. They are attractive therapeutic targets for treating myeloma patients. Conclusion: Addition of chemokine antagonists to current treatment regimens for myeloma should result in better therapeutic responses because of the loss of both the protective effect of the marrow microenvironment on the MM cells and the induction of osteoclast activity.",
author = "Rohit Aggarwal and Ghobrial, {Irene M.} and Roodman, {G. David}",
year = "2006",
month = "10",
doi = "10.1016/j.exphem.2006.06.017",
language = "English (US)",
volume = "34",
pages = "1289--1295",
journal = "Experimental Hematology",
issn = "0301-472X",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - Chemokines in multiple myeloma

AU - Aggarwal, Rohit

AU - Ghobrial, Irene M.

AU - Roodman, G. David

PY - 2006/10

Y1 - 2006/10

N2 - Objective: In this article we focus on the role that chemokines and chemokine receptors play in the pathogenesis of multiple myeloma and the associated bone destructive process, and consider their utility as novel therapeutic targets for treating this devastating disease. Methods: Current research on the role that chemokine and chemokine receptors play in the pathogenesis of myeloma is reviewed. Results: The chemokines, MIP-1α, MCP-1, IL-8, and SDF-1, and their receptors play important roles in homing of MM cells, tumor growth, and bone destruction in myeloma. They are attractive therapeutic targets for treating myeloma patients. Conclusion: Addition of chemokine antagonists to current treatment regimens for myeloma should result in better therapeutic responses because of the loss of both the protective effect of the marrow microenvironment on the MM cells and the induction of osteoclast activity.

AB - Objective: In this article we focus on the role that chemokines and chemokine receptors play in the pathogenesis of multiple myeloma and the associated bone destructive process, and consider their utility as novel therapeutic targets for treating this devastating disease. Methods: Current research on the role that chemokine and chemokine receptors play in the pathogenesis of myeloma is reviewed. Results: The chemokines, MIP-1α, MCP-1, IL-8, and SDF-1, and their receptors play important roles in homing of MM cells, tumor growth, and bone destruction in myeloma. They are attractive therapeutic targets for treating myeloma patients. Conclusion: Addition of chemokine antagonists to current treatment regimens for myeloma should result in better therapeutic responses because of the loss of both the protective effect of the marrow microenvironment on the MM cells and the induction of osteoclast activity.

UR - http://www.scopus.com/inward/record.url?scp=33748614845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748614845&partnerID=8YFLogxK

U2 - 10.1016/j.exphem.2006.06.017

DO - 10.1016/j.exphem.2006.06.017

M3 - Article

C2 - 16982321

AN - SCOPUS:33748614845

VL - 34

SP - 1289

EP - 1295

JO - Experimental Hematology

JF - Experimental Hematology

SN - 0301-472X

IS - 10

ER -