Chemokines

Signal lamps for trafficking of T and B cells for development and effector function

Chang H. Kim, Hal Broxmeyer

Research output: Contribution to journalArticle

295 Citations (Scopus)

Abstract

Chemokines can act as signal lamps for trafficking of lymphocytes at the important crossing points of lymphoid tissues. Lymphoid progenitors at different differentiation stages are differentially localized in primary lymphoid tissues and have differential responsiveness to thymic or bone marrow chemokines: SDF-1, CKβ-11/MIP-3β/ELC, SLC/6Ckine/Exodus2, MIP-1β, and TECK. Naive T cells and B cells circulate to secondary lymphoid tissues for possible activation. Chemokines, SDF-1, SLC/6Ckine/Exodus2, CKβ-11/MIP- 3β/ELC, BLC/BCA-1, and DC-CK1/PARC, are expressed in the specialized microenvironments of secondary lymphoid tissues and regulate the migration of naive lymphocytes. Effector lymphocytes express a different set of chemokine receptors from naive lymphocytes. T helper (Th) 0 and 1 cells predominantly express CXCR3 and CCR5, whereas Th2 cells express CCR3, CCR4, and CCR8, which, with other factors such as expression patterns of adhesion molecules, likely determine the tissue-specific infiltration of effector lymphocytes.

Original languageEnglish
Pages (from-to)6-15
Number of pages10
JournalJournal of Leukocyte Biology
Volume65
Issue number1
StatePublished - 1999

Fingerprint

Chemokines
Lymphoid Tissue
B-Lymphocytes
Lymphocytes
T-Lymphocytes
Chemokine CCL21
Th2 Cells
Th1 Cells
Chemokine Receptors
Bone Marrow

Keywords

  • Activated
  • Chemotaxis
  • Lymphocyte
  • Memory
  • Naive

ASJC Scopus subject areas

  • Cell Biology

Cite this

Chemokines : Signal lamps for trafficking of T and B cells for development and effector function. / Kim, Chang H.; Broxmeyer, Hal.

In: Journal of Leukocyte Biology, Vol. 65, No. 1, 1999, p. 6-15.

Research output: Contribution to journalArticle

@article{57b65ff9e3344481aa31363659bca7d1,
title = "Chemokines: Signal lamps for trafficking of T and B cells for development and effector function",
abstract = "Chemokines can act as signal lamps for trafficking of lymphocytes at the important crossing points of lymphoid tissues. Lymphoid progenitors at different differentiation stages are differentially localized in primary lymphoid tissues and have differential responsiveness to thymic or bone marrow chemokines: SDF-1, CKβ-11/MIP-3β/ELC, SLC/6Ckine/Exodus2, MIP-1β, and TECK. Naive T cells and B cells circulate to secondary lymphoid tissues for possible activation. Chemokines, SDF-1, SLC/6Ckine/Exodus2, CKβ-11/MIP- 3β/ELC, BLC/BCA-1, and DC-CK1/PARC, are expressed in the specialized microenvironments of secondary lymphoid tissues and regulate the migration of naive lymphocytes. Effector lymphocytes express a different set of chemokine receptors from naive lymphocytes. T helper (Th) 0 and 1 cells predominantly express CXCR3 and CCR5, whereas Th2 cells express CCR3, CCR4, and CCR8, which, with other factors such as expression patterns of adhesion molecules, likely determine the tissue-specific infiltration of effector lymphocytes.",
keywords = "Activated, Chemotaxis, Lymphocyte, Memory, Naive",
author = "Kim, {Chang H.} and Hal Broxmeyer",
year = "1999",
language = "English",
volume = "65",
pages = "6--15",
journal = "Journal of Leukocyte Biology",
issn = "0741-5400",
publisher = "FASEB",
number = "1",

}

TY - JOUR

T1 - Chemokines

T2 - Signal lamps for trafficking of T and B cells for development and effector function

AU - Kim, Chang H.

AU - Broxmeyer, Hal

PY - 1999

Y1 - 1999

N2 - Chemokines can act as signal lamps for trafficking of lymphocytes at the important crossing points of lymphoid tissues. Lymphoid progenitors at different differentiation stages are differentially localized in primary lymphoid tissues and have differential responsiveness to thymic or bone marrow chemokines: SDF-1, CKβ-11/MIP-3β/ELC, SLC/6Ckine/Exodus2, MIP-1β, and TECK. Naive T cells and B cells circulate to secondary lymphoid tissues for possible activation. Chemokines, SDF-1, SLC/6Ckine/Exodus2, CKβ-11/MIP- 3β/ELC, BLC/BCA-1, and DC-CK1/PARC, are expressed in the specialized microenvironments of secondary lymphoid tissues and regulate the migration of naive lymphocytes. Effector lymphocytes express a different set of chemokine receptors from naive lymphocytes. T helper (Th) 0 and 1 cells predominantly express CXCR3 and CCR5, whereas Th2 cells express CCR3, CCR4, and CCR8, which, with other factors such as expression patterns of adhesion molecules, likely determine the tissue-specific infiltration of effector lymphocytes.

AB - Chemokines can act as signal lamps for trafficking of lymphocytes at the important crossing points of lymphoid tissues. Lymphoid progenitors at different differentiation stages are differentially localized in primary lymphoid tissues and have differential responsiveness to thymic or bone marrow chemokines: SDF-1, CKβ-11/MIP-3β/ELC, SLC/6Ckine/Exodus2, MIP-1β, and TECK. Naive T cells and B cells circulate to secondary lymphoid tissues for possible activation. Chemokines, SDF-1, SLC/6Ckine/Exodus2, CKβ-11/MIP- 3β/ELC, BLC/BCA-1, and DC-CK1/PARC, are expressed in the specialized microenvironments of secondary lymphoid tissues and regulate the migration of naive lymphocytes. Effector lymphocytes express a different set of chemokine receptors from naive lymphocytes. T helper (Th) 0 and 1 cells predominantly express CXCR3 and CCR5, whereas Th2 cells express CCR3, CCR4, and CCR8, which, with other factors such as expression patterns of adhesion molecules, likely determine the tissue-specific infiltration of effector lymphocytes.

KW - Activated

KW - Chemotaxis

KW - Lymphocyte

KW - Memory

KW - Naive

UR - http://www.scopus.com/inward/record.url?scp=0032901694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032901694&partnerID=8YFLogxK

M3 - Article

VL - 65

SP - 6

EP - 15

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

SN - 0741-5400

IS - 1

ER -