Chemoprevention of metaplasia initiation and carcinogenic progression to esophageal adenocarcinoma by resveratrol supplementation

Charles E. Woodall, Yan Li, Hong Liu Qia, John Wo, Robert C G Martin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Resveratrol (3,5,4′-trihydroxy-frans-stilbene), a polyphenol found in the skin of the grape and red wine, has been found to have chemopreventitive effects in some carcinogenic models. The effects of resveratrol on the initiation of Barrett's metaplasia and the carcinogenic progression to esophageal adenocarcinoma have not been evaluated. The aim of this study was to evaluate the effects of resveratrol on the transition from reflux esophagitis to Barrett's metaplasia to dysplasia to esophageal adenocarcinoma in an established rat model. Male Sprague-Dawley rats underwent esophagoduodenal anastomosis as per institutional approved protocol. They were then treated twice weekly with intraperitoneal injection of 7 mg/kg of resveratrol or saline. Additional nonoperated rats served as controls. The rats in each group were assigned to 1, 3, or 5-month subgroups. The distal esophagus was preserved for blinded histopathological examination at the time of harvest Thirty-one animals in the 5-month resveratrol group showed a decreased severity of esophagitis (P

Original languageEnglish (US)
Pages (from-to)437-443
Number of pages7
JournalAnti-Cancer Drugs
Volume20
Issue number6
DOIs
StatePublished - Jul 2009
Externally publishedYes

Fingerprint

Chemoprevention
Metaplasia
Adenocarcinoma
Barrett Esophagus
Stilbenes
Peptic Esophagitis
Esophagitis
Vitis
Polyphenols
Wine
Intraperitoneal Injections
Esophagus
Sprague Dawley Rats
resveratrol
Skin

Keywords

  • Barrett's esophagus
  • Chemoprevention
  • Esophageal adenocarcinoma
  • Resveratrol

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cancer Research
  • Oncology

Cite this

Chemoprevention of metaplasia initiation and carcinogenic progression to esophageal adenocarcinoma by resveratrol supplementation. / Woodall, Charles E.; Li, Yan; Qia, Hong Liu; Wo, John; Martin, Robert C G.

In: Anti-Cancer Drugs, Vol. 20, No. 6, 07.2009, p. 437-443.

Research output: Contribution to journalArticle

Woodall, Charles E. ; Li, Yan ; Qia, Hong Liu ; Wo, John ; Martin, Robert C G. / Chemoprevention of metaplasia initiation and carcinogenic progression to esophageal adenocarcinoma by resveratrol supplementation. In: Anti-Cancer Drugs. 2009 ; Vol. 20, No. 6. pp. 437-443.
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