Chemotherapy effects on hepatoblastoma: A histological study

Romil Saxena, J. L. Leake, E. A. Shafford, M. Davenport, A. P. Mowat, J. Pritchard, G. Mieli-Vergani, E. R. Howard, L. Spitz, M. Malone, J. R. Salisbury

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The histopathological features of hepatoblastoma in 17 patients treated with preoperative chemotherapy were compared with those in 11 patients not subjected to chemotherapy during the same 11-year period. Tumor necrosis was more extensive in patients receiving preoperative chemotherapy. Two tumors, however, were apparently unaffected by chemotherapy. There was no obvious correlation between the extent of necrosis and the number of courses of chemotherapy. There also seems to be no evidence of preferential ablation of a particular morphological type of tumor. The most notable feature in cases treated with chemotherapy was the extensive presence of osteoid. Osteoid was present in 36% of untreated cases, occupying 40% of the surface area. This finding raises speculation about the role of chemotherapy in the maturation of tumors that have an inherent ability to differentiate. A long-term study is needed to clarify the prognostic significance of mature heterologous elements in hepatoblastoma.

Original languageEnglish (US)
Pages (from-to)1266-1271
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume17
Issue number12
DOIs
StatePublished - 1993
Externally publishedYes

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Hepatoblastoma
Drug Therapy
Neoplasms
Necrosis

Keywords

  • Chemotherapy
  • Hepatoblastoma
  • Maturation
  • Necrosis
  • Osteoid

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Saxena, R., Leake, J. L., Shafford, E. A., Davenport, M., Mowat, A. P., Pritchard, J., ... Salisbury, J. R. (1993). Chemotherapy effects on hepatoblastoma: A histological study. American Journal of Surgical Pathology, 17(12), 1266-1271. https://doi.org/10.1097/00000478-199312000-00008

Chemotherapy effects on hepatoblastoma : A histological study. / Saxena, Romil; Leake, J. L.; Shafford, E. A.; Davenport, M.; Mowat, A. P.; Pritchard, J.; Mieli-Vergani, G.; Howard, E. R.; Spitz, L.; Malone, M.; Salisbury, J. R.

In: American Journal of Surgical Pathology, Vol. 17, No. 12, 1993, p. 1266-1271.

Research output: Contribution to journalArticle

Saxena, R, Leake, JL, Shafford, EA, Davenport, M, Mowat, AP, Pritchard, J, Mieli-Vergani, G, Howard, ER, Spitz, L, Malone, M & Salisbury, JR 1993, 'Chemotherapy effects on hepatoblastoma: A histological study', American Journal of Surgical Pathology, vol. 17, no. 12, pp. 1266-1271. https://doi.org/10.1097/00000478-199312000-00008
Saxena, Romil ; Leake, J. L. ; Shafford, E. A. ; Davenport, M. ; Mowat, A. P. ; Pritchard, J. ; Mieli-Vergani, G. ; Howard, E. R. ; Spitz, L. ; Malone, M. ; Salisbury, J. R. / Chemotherapy effects on hepatoblastoma : A histological study. In: American Journal of Surgical Pathology. 1993 ; Vol. 17, No. 12. pp. 1266-1271.
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