Chemotherapy for disseminated testicular cancer.

Lawrence Einhorn, J. P. Donohue

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diaminedichloroplatinum, vinblastine, and bleomycin. Three patients were considered unevaluable due to early death. This chemotherapy regimen produced 74 per cent complete and 26 per cent partial remissions. Furthermore, five patients in partial remission became disease-free following the surgical removal of residual disease, producing an overall 85 per cent disease-free status. Toxicity, although significant during remission induction with cis-platinum, vinblastine, and bleomycin, was usually manageable. Maintenance therapy with vinblastine and BCG was very well tolerated, and only two patients in complete remission have experienced a relapse on maintenance therapy, one of whom had a central nervous system relapse. Thirty eight of these patients remain alive, and 32 remain alive and disease-free 6+ to 30+ months. We feel that this regimen represents a major advance in the management of patients with disseminated testicular cancer.

Original languageEnglish
Pages (from-to)407-426
Number of pages20
JournalUrologic Clinics of North America
Volume4
Issue number3
StatePublished - Oct 1977
Externally publishedYes

Fingerprint

Testicular Neoplasms
Drug Therapy
Vinblastine
Bleomycin
Remission Induction
Recurrence
Drug Combinations
Mycobacterium bovis
Cisplatin
Central Nervous System
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Chemotherapy for disseminated testicular cancer. / Einhorn, Lawrence; Donohue, J. P.

In: Urologic Clinics of North America, Vol. 4, No. 3, 10.1977, p. 407-426.

Research output: Contribution to journalArticle

@article{59761e597b174eb7bd7a5b994c419d5c,
title = "Chemotherapy for disseminated testicular cancer.",
abstract = "Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diaminedichloroplatinum, vinblastine, and bleomycin. Three patients were considered unevaluable due to early death. This chemotherapy regimen produced 74 per cent complete and 26 per cent partial remissions. Furthermore, five patients in partial remission became disease-free following the surgical removal of residual disease, producing an overall 85 per cent disease-free status. Toxicity, although significant during remission induction with cis-platinum, vinblastine, and bleomycin, was usually manageable. Maintenance therapy with vinblastine and BCG was very well tolerated, and only two patients in complete remission have experienced a relapse on maintenance therapy, one of whom had a central nervous system relapse. Thirty eight of these patients remain alive, and 32 remain alive and disease-free 6+ to 30+ months. We feel that this regimen represents a major advance in the management of patients with disseminated testicular cancer.",
author = "Lawrence Einhorn and Donohue, {J. P.}",
year = "1977",
month = "10",
language = "English",
volume = "4",
pages = "407--426",
journal = "Urologic Clinics of North America",
issn = "0094-0143",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Chemotherapy for disseminated testicular cancer.

AU - Einhorn, Lawrence

AU - Donohue, J. P.

PY - 1977/10

Y1 - 1977/10

N2 - Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diaminedichloroplatinum, vinblastine, and bleomycin. Three patients were considered unevaluable due to early death. This chemotherapy regimen produced 74 per cent complete and 26 per cent partial remissions. Furthermore, five patients in partial remission became disease-free following the surgical removal of residual disease, producing an overall 85 per cent disease-free status. Toxicity, although significant during remission induction with cis-platinum, vinblastine, and bleomycin, was usually manageable. Maintenance therapy with vinblastine and BCG was very well tolerated, and only two patients in complete remission have experienced a relapse on maintenance therapy, one of whom had a central nervous system relapse. Thirty eight of these patients remain alive, and 32 remain alive and disease-free 6+ to 30+ months. We feel that this regimen represents a major advance in the management of patients with disseminated testicular cancer.

AB - Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diaminedichloroplatinum, vinblastine, and bleomycin. Three patients were considered unevaluable due to early death. This chemotherapy regimen produced 74 per cent complete and 26 per cent partial remissions. Furthermore, five patients in partial remission became disease-free following the surgical removal of residual disease, producing an overall 85 per cent disease-free status. Toxicity, although significant during remission induction with cis-platinum, vinblastine, and bleomycin, was usually manageable. Maintenance therapy with vinblastine and BCG was very well tolerated, and only two patients in complete remission have experienced a relapse on maintenance therapy, one of whom had a central nervous system relapse. Thirty eight of these patients remain alive, and 32 remain alive and disease-free 6+ to 30+ months. We feel that this regimen represents a major advance in the management of patients with disseminated testicular cancer.

UR - http://www.scopus.com/inward/record.url?scp=0017542077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017542077&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 407

EP - 426

JO - Urologic Clinics of North America

JF - Urologic Clinics of North America

SN - 0094-0143

IS - 3

ER -