Chemotherapy induced DNA damage response Convergence of drugs and pathways

Derek Woods, John J. Turchi

Research output: Contribution to journalReview article

86 Scopus citations

Abstract

Chemotherapeutics target rapidly dividing cancer cells by directly or indirectly inducing DNA damage. Upon recognizing DNA damage, cells initiate a variety of signaling pathways collectively referred to as the DNA damage response (DDR). Interestingly, the pathways used to elicit this response are as varied as the types of DNA damage induced. However, the activation of these various pathways has similar results including DNA repair, suppression of global general translation, cell cycle arrest and, ultimately, either cell survival or cell death. This review will focus on a series of chemotherapy-induced DNA lesions and highlight recent advances in our understanding of the DDR, the DNA repair pathways it activates and the cellular consequences of these converging pathways.

Original languageEnglish (US)
Pages (from-to)379-389
Number of pages11
JournalCancer Biology and Therapy
Volume14
Issue number5
DOIs
StatePublished - May 1 2013

Keywords

  • ATM
  • ATR
  • Chemotherapy
  • Cisplatin
  • DNA damage
  • DNA-PK
  • PIKK
  • Signaling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Medicine
  • Pharmacology

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