Chemotherapy-induced sclerosing cholangitis

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aim: To review the computed tomography (CT), magnetic resonance imaging (MRI) and cholangiographic findings of chemotherapy-induced sclerosing cholangitis (CISC). Methods: Between January 1995 and December 2004, 11 patients in the endoscopic retrograde cholangiography database were identified with CISC. Twelve CT, four MRI, 69 endoscopic and nine antegrade cholangiographic studies in these patients were reviewed. Serial change in appearance and response to endoscopic treatment were recorded. Results: CISC showed segmental irregular biliary dilatation with strictures of proximal extrahepatic bile ducts. The distal 5 cm of common bile duct was not affected in any patient. CT and MRI findings included altered vascular perfusion of one or more liver segments, liver metastases or peritoneal carcinomatosis. Biliary strictures needed repeated stenting in 10 patients (mean: every 4.7 months). Cirrhosis (n = 1) or confluent fibrosis (n = 0) were uncommon findings. Conclusion: CISC shares similar cholangiographic appearances to primary sclerosing cholangitis (PSC). Unlike PSC, biliary disease primarily involved ducts at the hepatic porta rather than intrahepatic ducts. Multiphasic contrast-enhanced CT or MRI may show evidence of perfusion abnormalities, cavitary liver lesions, or metastatic disease.

Original languageEnglish
Pages (from-to)670-678
Number of pages9
JournalClinical Radiology
Volume61
Issue number8
DOIs
StatePublished - Aug 2006

Fingerprint

Sclerosing Cholangitis
Drug Therapy
Tomography
Magnetic Resonance Imaging
Liver
Pathologic Constriction
Fibrosis
Perfusion
Extrahepatic Bile Ducts
Common Hepatic Duct
Cholangiography
Common Bile Duct
Blood Vessels
Dilatation
Databases
Neoplasm Metastasis
Carcinoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Chemotherapy-induced sclerosing cholangitis. / Sandrasegaran, Kumar; Alazmi, W. M.; Tann, M.; Fogel, Evan; McHenry, Lee; Lehman, Glen.

In: Clinical Radiology, Vol. 61, No. 8, 08.2006, p. 670-678.

Research output: Contribution to journalArticle

@article{1626cfe575bd420d9508e9849a49ba49,
title = "Chemotherapy-induced sclerosing cholangitis",
abstract = "Aim: To review the computed tomography (CT), magnetic resonance imaging (MRI) and cholangiographic findings of chemotherapy-induced sclerosing cholangitis (CISC). Methods: Between January 1995 and December 2004, 11 patients in the endoscopic retrograde cholangiography database were identified with CISC. Twelve CT, four MRI, 69 endoscopic and nine antegrade cholangiographic studies in these patients were reviewed. Serial change in appearance and response to endoscopic treatment were recorded. Results: CISC showed segmental irregular biliary dilatation with strictures of proximal extrahepatic bile ducts. The distal 5 cm of common bile duct was not affected in any patient. CT and MRI findings included altered vascular perfusion of one or more liver segments, liver metastases or peritoneal carcinomatosis. Biliary strictures needed repeated stenting in 10 patients (mean: every 4.7 months). Cirrhosis (n = 1) or confluent fibrosis (n = 0) were uncommon findings. Conclusion: CISC shares similar cholangiographic appearances to primary sclerosing cholangitis (PSC). Unlike PSC, biliary disease primarily involved ducts at the hepatic porta rather than intrahepatic ducts. Multiphasic contrast-enhanced CT or MRI may show evidence of perfusion abnormalities, cavitary liver lesions, or metastatic disease.",
author = "Kumar Sandrasegaran and Alazmi, {W. M.} and M. Tann and Evan Fogel and Lee McHenry and Glen Lehman",
year = "2006",
month = "8",
doi = "10.1016/j.crad.2006.02.013",
language = "English",
volume = "61",
pages = "670--678",
journal = "Clinical Radiology",
issn = "0009-9260",
publisher = "W.B. Saunders Ltd",
number = "8",

}

TY - JOUR

T1 - Chemotherapy-induced sclerosing cholangitis

AU - Sandrasegaran, Kumar

AU - Alazmi, W. M.

AU - Tann, M.

AU - Fogel, Evan

AU - McHenry, Lee

AU - Lehman, Glen

PY - 2006/8

Y1 - 2006/8

N2 - Aim: To review the computed tomography (CT), magnetic resonance imaging (MRI) and cholangiographic findings of chemotherapy-induced sclerosing cholangitis (CISC). Methods: Between January 1995 and December 2004, 11 patients in the endoscopic retrograde cholangiography database were identified with CISC. Twelve CT, four MRI, 69 endoscopic and nine antegrade cholangiographic studies in these patients were reviewed. Serial change in appearance and response to endoscopic treatment were recorded. Results: CISC showed segmental irregular biliary dilatation with strictures of proximal extrahepatic bile ducts. The distal 5 cm of common bile duct was not affected in any patient. CT and MRI findings included altered vascular perfusion of one or more liver segments, liver metastases or peritoneal carcinomatosis. Biliary strictures needed repeated stenting in 10 patients (mean: every 4.7 months). Cirrhosis (n = 1) or confluent fibrosis (n = 0) were uncommon findings. Conclusion: CISC shares similar cholangiographic appearances to primary sclerosing cholangitis (PSC). Unlike PSC, biliary disease primarily involved ducts at the hepatic porta rather than intrahepatic ducts. Multiphasic contrast-enhanced CT or MRI may show evidence of perfusion abnormalities, cavitary liver lesions, or metastatic disease.

AB - Aim: To review the computed tomography (CT), magnetic resonance imaging (MRI) and cholangiographic findings of chemotherapy-induced sclerosing cholangitis (CISC). Methods: Between January 1995 and December 2004, 11 patients in the endoscopic retrograde cholangiography database were identified with CISC. Twelve CT, four MRI, 69 endoscopic and nine antegrade cholangiographic studies in these patients were reviewed. Serial change in appearance and response to endoscopic treatment were recorded. Results: CISC showed segmental irregular biliary dilatation with strictures of proximal extrahepatic bile ducts. The distal 5 cm of common bile duct was not affected in any patient. CT and MRI findings included altered vascular perfusion of one or more liver segments, liver metastases or peritoneal carcinomatosis. Biliary strictures needed repeated stenting in 10 patients (mean: every 4.7 months). Cirrhosis (n = 1) or confluent fibrosis (n = 0) were uncommon findings. Conclusion: CISC shares similar cholangiographic appearances to primary sclerosing cholangitis (PSC). Unlike PSC, biliary disease primarily involved ducts at the hepatic porta rather than intrahepatic ducts. Multiphasic contrast-enhanced CT or MRI may show evidence of perfusion abnormalities, cavitary liver lesions, or metastatic disease.

UR - http://www.scopus.com/inward/record.url?scp=33745853493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745853493&partnerID=8YFLogxK

U2 - 10.1016/j.crad.2006.02.013

DO - 10.1016/j.crad.2006.02.013

M3 - Article

VL - 61

SP - 670

EP - 678

JO - Clinical Radiology

JF - Clinical Radiology

SN - 0009-9260

IS - 8

ER -