Chemotherapy-related complications in the kidneys and collecting system: an imaging perspective

Jemianne Bautista Jia, Chandana Lall, Temel Tirkes, Rajesh Gulati, Ramit Lamba, Scott C. Goodwin

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Abstract: Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. The agents most commonly associated with chemotherapy-associated nephrotoxicity are methotrexate, semustine, streptozocin, mithramycin, and cisplatin. Certain chemotherapeutic agents have adverse effects on the kidneys and urothelium that can be visualized radiographically, including cystic change, interstitial nephritis, papillary necrosis, urothelial changes, haemorrhagic cystitis, acute tubular necrosis, and infarction. This review focuses on imaging features identifying complications of chemotherapy in the kidneys and collecting system and provides didactic cases to alert referring clinicians. Teaching Points: • Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. • Chemotherapies have adverse renal and urothelial effects that can be visualized radiographically. • Crizotinib use can result in the development of complex renal cysts.

Original languageEnglish (US)
Pages (from-to)479-487
Number of pages9
JournalInsights into Imaging
Volume6
Issue number4
DOIs
StatePublished - Aug 29 2015

Keywords

  • Biologic agents
  • Chemotherapy
  • Drug-associated adverse effects
  • Nephrotoxicity
  • Renal cysts

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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