Chiari I malformation: Association with hypophosphatemic rickets and MR imaging appearance

K. S. Caldemeyer, J. C. Boaz, R. S. Wappner, C. C. Moran, R. R. Smith, J. P. Quets

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

PURPOSE: To evaluate for an association between familial hypophosphatemic rickets (FHR) and Chiari I malformation (CM1). MATERIALS AND METHODS: Sixteen patients with FHR underwent magnetic resonance (MR) imaging of the cervicomedullary junction. Images were analyzed by three radiologists for cerebellar tonsillar ectopia, syringohydromyelia, calvarial bone thickening, a flat posterior fossa, and cervical spinal stenosis. Final diagnoses were made by means of consensus. Tonsillar ectopia of 4 mm indicated CM1. Subjects underwent neurologic examination and completed a questionnaire. Medical records were retrospectively reviewed. A two-sided Fisher exact test was used to test for independence between CM1 and bone thickening or ventriculomegaly. RESULTS: Seven subjects (44%) had CM1. The more severe the bone thickening, the more likely that a CM1 was present. Four subjects (25%) had cervical spinal stenosis. CONCLUSION: Findings indicate that CM1 is associated with FHR and that the primary abnormality in patients with CM1 is a small posterior fossa caused by a bony malformation.

Original languageEnglish
Pages (from-to)733-738
Number of pages6
JournalRadiology
Volume195
Issue number3
StatePublished - 1995

Fingerprint

Familial Hypophosphatemic Rickets
Hypophosphatemic Rickets
Spinal Stenosis
Magnetic Resonance Imaging
Bone and Bones
Neurologic Examination
Medical Records

Keywords

  • Brain, abnormalities
  • Rickets

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Caldemeyer, K. S., Boaz, J. C., Wappner, R. S., Moran, C. C., Smith, R. R., & Quets, J. P. (1995). Chiari I malformation: Association with hypophosphatemic rickets and MR imaging appearance. Radiology, 195(3), 733-738.

Chiari I malformation : Association with hypophosphatemic rickets and MR imaging appearance. / Caldemeyer, K. S.; Boaz, J. C.; Wappner, R. S.; Moran, C. C.; Smith, R. R.; Quets, J. P.

In: Radiology, Vol. 195, No. 3, 1995, p. 733-738.

Research output: Contribution to journalArticle

Caldemeyer, KS, Boaz, JC, Wappner, RS, Moran, CC, Smith, RR & Quets, JP 1995, 'Chiari I malformation: Association with hypophosphatemic rickets and MR imaging appearance', Radiology, vol. 195, no. 3, pp. 733-738.
Caldemeyer KS, Boaz JC, Wappner RS, Moran CC, Smith RR, Quets JP. Chiari I malformation: Association with hypophosphatemic rickets and MR imaging appearance. Radiology. 1995;195(3):733-738.
Caldemeyer, K. S. ; Boaz, J. C. ; Wappner, R. S. ; Moran, C. C. ; Smith, R. R. ; Quets, J. P. / Chiari I malformation : Association with hypophosphatemic rickets and MR imaging appearance. In: Radiology. 1995 ; Vol. 195, No. 3. pp. 733-738.
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