Childhood brain tumor: presentation at younger age is associated with a family tumor history

Andrew Sussman, Alan Leviton, Elizabeth N. Allred, Carol Aschenbrener, Donald F. Austin, Floyd H. Gilles, E. Tessa Hedley-Whyte, Laurence N. Kolonel, Joseph L. Lyon, G. Marie Swanson, Dee West

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In a registry-based sample of 361 children with a brain tumor, those whose grandparents and great-grandparents had a history of any kind of tumor were younger at the time of presentation than were those who lacked this family history (p=0.1). In post hoc analyses, the age difference was most apparent among children with cerebral tumors, and when family history was limited to brain tumors and to great-grandparents. These findings are in keeping with the hypothesis that a familial tumor diathesis contributes to an early age at onset of a brain tumor in some children.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalCancer Causes and Control
Volume1
Issue number1
DOIs
StatePublished - Jul 1990
Externally publishedYes

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Brain Neoplasms
Neoplasms
Disease Susceptibility
Age of Onset
Registries
Grandparents

Keywords

  • Brain
  • child
  • neoplasms
  • theoretical models

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Sussman, A., Leviton, A., Allred, E. N., Aschenbrener, C., Austin, D. F., Gilles, F. H., ... West, D. (1990). Childhood brain tumor: presentation at younger age is associated with a family tumor history. Cancer Causes and Control, 1(1), 75-79. https://doi.org/10.1007/BF00053186

Childhood brain tumor : presentation at younger age is associated with a family tumor history. / Sussman, Andrew; Leviton, Alan; Allred, Elizabeth N.; Aschenbrener, Carol; Austin, Donald F.; Gilles, Floyd H.; Hedley-Whyte, E. Tessa; Kolonel, Laurence N.; Lyon, Joseph L.; Swanson, G. Marie; West, Dee.

In: Cancer Causes and Control, Vol. 1, No. 1, 07.1990, p. 75-79.

Research output: Contribution to journalArticle

Sussman, A, Leviton, A, Allred, EN, Aschenbrener, C, Austin, DF, Gilles, FH, Hedley-Whyte, ET, Kolonel, LN, Lyon, JL, Swanson, GM & West, D 1990, 'Childhood brain tumor: presentation at younger age is associated with a family tumor history', Cancer Causes and Control, vol. 1, no. 1, pp. 75-79. https://doi.org/10.1007/BF00053186
Sussman A, Leviton A, Allred EN, Aschenbrener C, Austin DF, Gilles FH et al. Childhood brain tumor: presentation at younger age is associated with a family tumor history. Cancer Causes and Control. 1990 Jul;1(1):75-79. https://doi.org/10.1007/BF00053186
Sussman, Andrew ; Leviton, Alan ; Allred, Elizabeth N. ; Aschenbrener, Carol ; Austin, Donald F. ; Gilles, Floyd H. ; Hedley-Whyte, E. Tessa ; Kolonel, Laurence N. ; Lyon, Joseph L. ; Swanson, G. Marie ; West, Dee. / Childhood brain tumor : presentation at younger age is associated with a family tumor history. In: Cancer Causes and Control. 1990 ; Vol. 1, No. 1. pp. 75-79.
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