Childhood brain tumor: presentation at younger age is associated with a family tumor history

Andrew Sussman, Alan Leviton, Elizabeth N. Allred, Carol Aschenbrener, Donald F. Austin, Floyd H. Gilles, E. Tessa Hedley-Whyte, Laurence N. Kolonel, Joseph L. Lyon, G. Marie Swanson, Dee West

    Research output: Contribution to journalArticle

    13 Scopus citations

    Abstract

    In a registry-based sample of 361 children with a brain tumor, those whose grandparents and great-grandparents had a history of any kind of tumor were younger at the time of presentation than were those who lacked this family history (p=0.1). In post hoc analyses, the age difference was most apparent among children with cerebral tumors, and when family history was limited to brain tumors and to great-grandparents. These findings are in keeping with the hypothesis that a familial tumor diathesis contributes to an early age at onset of a brain tumor in some children.

    Original languageEnglish (US)
    Pages (from-to)75-79
    Number of pages5
    JournalCancer Causes and Control
    Volume1
    Issue number1
    DOIs
    StatePublished - Jul 1 1990

    Keywords

    • Brain
    • child
    • neoplasms
    • theoretical models

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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  • Cite this

    Sussman, A., Leviton, A., Allred, E. N., Aschenbrener, C., Austin, D. F., Gilles, F. H., Hedley-Whyte, E. T., Kolonel, L. N., Lyon, J. L., Swanson, G. M., & West, D. (1990). Childhood brain tumor: presentation at younger age is associated with a family tumor history. Cancer Causes and Control, 1(1), 75-79. https://doi.org/10.1007/BF00053186