Childhood obesity and type 2 diabetes mellitus

Tamara Hannon, Goutham Rao, Silva A. Arslanian

Research output: Contribution to journalArticle

275 Citations (Scopus)

Abstract

Until recently, the majority of cases of diabetes mellitus among children and adolescents were immune-mediated type 1a diabetes. Obesity has led to a dramatic increase in the incidence of type 2 diabetes (T2DM) among children and adolescents over the past 2 decades. Obesity is strongly associated with insulin resistance, which, when coupled with relative insulin deficiency, leads to the development of overt T2DM. Children and adolescents with T2DM may experience the microvascular and macrovascular complications of this disease at younger ages than individuals who develop diabetes in adulthood, including atherosclerotic cardiovascular disease, stroke, myocardial infarction, and sudden death; renal insufficiency and chronic renal failure; limb-threatening neuropathy and vasculopathy; and retinopathy leading to blindness. Health care professionals are advised to perform the appropriate screening in children at risk for T2DM, diagnose the condition as early as possible, and provide rigorous management of the disease.

Original languageEnglish (US)
Pages (from-to)473-480
Number of pages8
JournalPediatrics
Volume116
Issue number2
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Pediatric Obesity
Type 2 Diabetes Mellitus
Obesity
Myocardial Infarction
Blindness
Disease Management
Sudden Death
Chronic Kidney Failure
Renal Insufficiency
Insulin Resistance
Diabetes Mellitus
Cardiovascular Diseases
Extremities
Insulin
Delivery of Health Care
Incidence

Keywords

  • Children
  • Insulin
  • Insulin resistance
  • Obesity
  • Oral hypoglycemic agents
  • Prediabetes
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Childhood obesity and type 2 diabetes mellitus. / Hannon, Tamara; Rao, Goutham; Arslanian, Silva A.

In: Pediatrics, Vol. 116, No. 2, 2005, p. 473-480.

Research output: Contribution to journalArticle

Hannon, Tamara ; Rao, Goutham ; Arslanian, Silva A. / Childhood obesity and type 2 diabetes mellitus. In: Pediatrics. 2005 ; Vol. 116, No. 2. pp. 473-480.
@article{f542dc99bbb54b3e91c392c80945aa92,
title = "Childhood obesity and type 2 diabetes mellitus",
abstract = "Until recently, the majority of cases of diabetes mellitus among children and adolescents were immune-mediated type 1a diabetes. Obesity has led to a dramatic increase in the incidence of type 2 diabetes (T2DM) among children and adolescents over the past 2 decades. Obesity is strongly associated with insulin resistance, which, when coupled with relative insulin deficiency, leads to the development of overt T2DM. Children and adolescents with T2DM may experience the microvascular and macrovascular complications of this disease at younger ages than individuals who develop diabetes in adulthood, including atherosclerotic cardiovascular disease, stroke, myocardial infarction, and sudden death; renal insufficiency and chronic renal failure; limb-threatening neuropathy and vasculopathy; and retinopathy leading to blindness. Health care professionals are advised to perform the appropriate screening in children at risk for T2DM, diagnose the condition as early as possible, and provide rigorous management of the disease.",
keywords = "Children, Insulin, Insulin resistance, Obesity, Oral hypoglycemic agents, Prediabetes, Type 2 diabetes mellitus",
author = "Tamara Hannon and Goutham Rao and Arslanian, {Silva A.}",
year = "2005",
doi = "10.1542/peds.2004-2536",
language = "English (US)",
volume = "116",
pages = "473--480",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "2",

}

TY - JOUR

T1 - Childhood obesity and type 2 diabetes mellitus

AU - Hannon, Tamara

AU - Rao, Goutham

AU - Arslanian, Silva A.

PY - 2005

Y1 - 2005

N2 - Until recently, the majority of cases of diabetes mellitus among children and adolescents were immune-mediated type 1a diabetes. Obesity has led to a dramatic increase in the incidence of type 2 diabetes (T2DM) among children and adolescents over the past 2 decades. Obesity is strongly associated with insulin resistance, which, when coupled with relative insulin deficiency, leads to the development of overt T2DM. Children and adolescents with T2DM may experience the microvascular and macrovascular complications of this disease at younger ages than individuals who develop diabetes in adulthood, including atherosclerotic cardiovascular disease, stroke, myocardial infarction, and sudden death; renal insufficiency and chronic renal failure; limb-threatening neuropathy and vasculopathy; and retinopathy leading to blindness. Health care professionals are advised to perform the appropriate screening in children at risk for T2DM, diagnose the condition as early as possible, and provide rigorous management of the disease.

AB - Until recently, the majority of cases of diabetes mellitus among children and adolescents were immune-mediated type 1a diabetes. Obesity has led to a dramatic increase in the incidence of type 2 diabetes (T2DM) among children and adolescents over the past 2 decades. Obesity is strongly associated with insulin resistance, which, when coupled with relative insulin deficiency, leads to the development of overt T2DM. Children and adolescents with T2DM may experience the microvascular and macrovascular complications of this disease at younger ages than individuals who develop diabetes in adulthood, including atherosclerotic cardiovascular disease, stroke, myocardial infarction, and sudden death; renal insufficiency and chronic renal failure; limb-threatening neuropathy and vasculopathy; and retinopathy leading to blindness. Health care professionals are advised to perform the appropriate screening in children at risk for T2DM, diagnose the condition as early as possible, and provide rigorous management of the disease.

KW - Children

KW - Insulin

KW - Insulin resistance

KW - Obesity

KW - Oral hypoglycemic agents

KW - Prediabetes

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=27844483012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27844483012&partnerID=8YFLogxK

U2 - 10.1542/peds.2004-2536

DO - 10.1542/peds.2004-2536

M3 - Article

C2 - 16061606

AN - SCOPUS:27844483012

VL - 116

SP - 473

EP - 480

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 2

ER -