Chlorhexidine and preservation of sound tooth structure in older adults: A placebo-controlled trial

C. C L Wyatt, Gerardo Maupome, P. P. Hujoel, M. I. MacEntee, G. R. Persson, R. E. Persson, H. A. Kiyak

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The Trial to Enhance Elderly Teeth Health (TEETH) was designed to test the impact of regular rinsing with a 0.12% chlorhexidine (CHX) solution on tooth loss, and the causes of tooth loss (caries, periodontal disease and trauma) were also investigated. This paper reports on the effectiveness of a 0.12% CHX solution for controlling caries using a tooth surface (coronal and root) survival analysis. A total of 1,101 low income elders in Seattle (United States) and Vancouver (Canada), aged 60-75 years, were recruited for a double-blind clinical trial and assigned to either a CHX (n = 550) or a placebo (n = 551) mouth rinse. Subjects alternated between daily rinsing for 1 month, followed by weekly rinsing for 5 months. All sound coronal and root surfaces at baseline were followed annually for up to 5 years. At each follow-up examination, those tooth surfaces with caries, restored, or extracted were scored as 'carious'. The hazard ratio associated with CHX for a sound surface to become filled, decayed, or extracted was 0.87 for coronal surfaces (95% confidence interval: 0.71-1.14, p = 0.20) and 0.91 for root surfaces (95% confidence interval: 0.73-1.14, p = 0.41). These findings suggest that regular rinsing with CHX does not have a substantial effect on the preservation of sound tooth structure in older adults.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalCaries Research
Volume41
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Chlorhexidine
Tooth
Placebos
Tooth Loss
Confidence Intervals
Periodontal Diseases
Survival Analysis
Canada
Mouth
Clinical Trials
Health
Wounds and Injuries

Keywords

  • Chlorhexidine, caries prevention
  • Coronal caries
  • Gerodontology
  • Root caries

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Wyatt, C. C. L., Maupome, G., Hujoel, P. P., MacEntee, M. I., Persson, G. R., Persson, R. E., & Kiyak, H. A. (2007). Chlorhexidine and preservation of sound tooth structure in older adults: A placebo-controlled trial. Caries Research, 41(2), 93-101. https://doi.org/10.1159/000098041

Chlorhexidine and preservation of sound tooth structure in older adults : A placebo-controlled trial. / Wyatt, C. C L; Maupome, Gerardo; Hujoel, P. P.; MacEntee, M. I.; Persson, G. R.; Persson, R. E.; Kiyak, H. A.

In: Caries Research, Vol. 41, No. 2, 02.2007, p. 93-101.

Research output: Contribution to journalArticle

Wyatt, CCL, Maupome, G, Hujoel, PP, MacEntee, MI, Persson, GR, Persson, RE & Kiyak, HA 2007, 'Chlorhexidine and preservation of sound tooth structure in older adults: A placebo-controlled trial', Caries Research, vol. 41, no. 2, pp. 93-101. https://doi.org/10.1159/000098041
Wyatt, C. C L ; Maupome, Gerardo ; Hujoel, P. P. ; MacEntee, M. I. ; Persson, G. R. ; Persson, R. E. ; Kiyak, H. A. / Chlorhexidine and preservation of sound tooth structure in older adults : A placebo-controlled trial. In: Caries Research. 2007 ; Vol. 41, No. 2. pp. 93-101.
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