Cholangiocarcinoma in patients with primary sclerosing cholangitis

A multicenter case-control study

Naga Chalasani, Arthur Baluyut, Ayaaz Ismail, Atif Zaman, Gagan Sood, Reem Ghalib, T. M. McCashland, K. Rajender Reddy, Xaralambos Zervos, Mann A. Anbari, Helena Hoen

Research output: Contribution to journalArticle

277 Citations (Scopus)

Abstract

Patients with primary sclerosing cholangitis (PSC) have a significantly increased risk of developing cholangiocarcinoma (CCA). Risk factors for developing such a complication are not well defined. We conducted a multicenter, case-control study to determine the risk factors and possible predictors for CCA in patients with PSC. The demographic, clinical, and laboratory features of 26 PSC patients with CCA diagnosed over a 7-year period at eight academic centers were compared with 87 patients with PSC but no CCA (controls). There was no statistically significant difference in demographics, smoking, signs or symptoms or complications of PSC, indices of disease severity (Mayo Risk score or Child-Pugh score), frequency or duration or complications of inflammatory bowel disease (IBD), frequency of biliary surgery, or therapeutic endoscopy between the two groups. Alcohol consumption was significantly associated with CCA in patients with PSC (odds ratio: 2.95; 95% CI: 1.04-8.3). Serum carbohydrate antigen 19-9 (CA 19-9) was significantly higher in patients with CCA than those without (177 ± 89 and 61 ± 58 U/mL, respectively; P = .002). A serum CA 19-9 level > 100 U/mL had 75% sensitivity and 80% specificity in identifying PSC patients with CCA. In conclusion, alcohol consumption was a risk factor for having CCA in PSC patients. The indices of severity of liver disease were not associated with CCA in patients with PSC. Serum CA 19-9 appeared to have good ability to discriminate PSC patients with and without CCA.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalHepatology
Volume31
Issue number1
StatePublished - 2000

Fingerprint

Sclerosing Cholangitis
Cholangiocarcinoma
Case-Control Studies
Carbohydrates
Antigens
Alcohol Drinking
Serum
Demography
Aptitude
Inflammatory Bowel Diseases
Endoscopy
Signs and Symptoms
Liver Diseases
Smoking
Odds Ratio
Sensitivity and Specificity

ASJC Scopus subject areas

  • Hepatology

Cite this

Chalasani, N., Baluyut, A., Ismail, A., Zaman, A., Sood, G., Ghalib, R., ... Hoen, H. (2000). Cholangiocarcinoma in patients with primary sclerosing cholangitis: A multicenter case-control study. Hepatology, 31(1), 7-11.

Cholangiocarcinoma in patients with primary sclerosing cholangitis : A multicenter case-control study. / Chalasani, Naga; Baluyut, Arthur; Ismail, Ayaaz; Zaman, Atif; Sood, Gagan; Ghalib, Reem; McCashland, T. M.; Rajender Reddy, K.; Zervos, Xaralambos; Anbari, Mann A.; Hoen, Helena.

In: Hepatology, Vol. 31, No. 1, 2000, p. 7-11.

Research output: Contribution to journalArticle

Chalasani, N, Baluyut, A, Ismail, A, Zaman, A, Sood, G, Ghalib, R, McCashland, TM, Rajender Reddy, K, Zervos, X, Anbari, MA & Hoen, H 2000, 'Cholangiocarcinoma in patients with primary sclerosing cholangitis: A multicenter case-control study', Hepatology, vol. 31, no. 1, pp. 7-11.
Chalasani, Naga ; Baluyut, Arthur ; Ismail, Ayaaz ; Zaman, Atif ; Sood, Gagan ; Ghalib, Reem ; McCashland, T. M. ; Rajender Reddy, K. ; Zervos, Xaralambos ; Anbari, Mann A. ; Hoen, Helena. / Cholangiocarcinoma in patients with primary sclerosing cholangitis : A multicenter case-control study. In: Hepatology. 2000 ; Vol. 31, No. 1. pp. 7-11.
@article{26665dbe0c0e43b38f1af7166dff3f33,
title = "Cholangiocarcinoma in patients with primary sclerosing cholangitis: A multicenter case-control study",
abstract = "Patients with primary sclerosing cholangitis (PSC) have a significantly increased risk of developing cholangiocarcinoma (CCA). Risk factors for developing such a complication are not well defined. We conducted a multicenter, case-control study to determine the risk factors and possible predictors for CCA in patients with PSC. The demographic, clinical, and laboratory features of 26 PSC patients with CCA diagnosed over a 7-year period at eight academic centers were compared with 87 patients with PSC but no CCA (controls). There was no statistically significant difference in demographics, smoking, signs or symptoms or complications of PSC, indices of disease severity (Mayo Risk score or Child-Pugh score), frequency or duration or complications of inflammatory bowel disease (IBD), frequency of biliary surgery, or therapeutic endoscopy between the two groups. Alcohol consumption was significantly associated with CCA in patients with PSC (odds ratio: 2.95; 95{\%} CI: 1.04-8.3). Serum carbohydrate antigen 19-9 (CA 19-9) was significantly higher in patients with CCA than those without (177 ± 89 and 61 ± 58 U/mL, respectively; P = .002). A serum CA 19-9 level > 100 U/mL had 75{\%} sensitivity and 80{\%} specificity in identifying PSC patients with CCA. In conclusion, alcohol consumption was a risk factor for having CCA in PSC patients. The indices of severity of liver disease were not associated with CCA in patients with PSC. Serum CA 19-9 appeared to have good ability to discriminate PSC patients with and without CCA.",
author = "Naga Chalasani and Arthur Baluyut and Ayaaz Ismail and Atif Zaman and Gagan Sood and Reem Ghalib and McCashland, {T. M.} and {Rajender Reddy}, K. and Xaralambos Zervos and Anbari, {Mann A.} and Helena Hoen",
year = "2000",
language = "English",
volume = "31",
pages = "7--11",
journal = "Hepatology",
issn = "0270-9139",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Cholangiocarcinoma in patients with primary sclerosing cholangitis

T2 - A multicenter case-control study

AU - Chalasani, Naga

AU - Baluyut, Arthur

AU - Ismail, Ayaaz

AU - Zaman, Atif

AU - Sood, Gagan

AU - Ghalib, Reem

AU - McCashland, T. M.

AU - Rajender Reddy, K.

AU - Zervos, Xaralambos

AU - Anbari, Mann A.

AU - Hoen, Helena

PY - 2000

Y1 - 2000

N2 - Patients with primary sclerosing cholangitis (PSC) have a significantly increased risk of developing cholangiocarcinoma (CCA). Risk factors for developing such a complication are not well defined. We conducted a multicenter, case-control study to determine the risk factors and possible predictors for CCA in patients with PSC. The demographic, clinical, and laboratory features of 26 PSC patients with CCA diagnosed over a 7-year period at eight academic centers were compared with 87 patients with PSC but no CCA (controls). There was no statistically significant difference in demographics, smoking, signs or symptoms or complications of PSC, indices of disease severity (Mayo Risk score or Child-Pugh score), frequency or duration or complications of inflammatory bowel disease (IBD), frequency of biliary surgery, or therapeutic endoscopy between the two groups. Alcohol consumption was significantly associated with CCA in patients with PSC (odds ratio: 2.95; 95% CI: 1.04-8.3). Serum carbohydrate antigen 19-9 (CA 19-9) was significantly higher in patients with CCA than those without (177 ± 89 and 61 ± 58 U/mL, respectively; P = .002). A serum CA 19-9 level > 100 U/mL had 75% sensitivity and 80% specificity in identifying PSC patients with CCA. In conclusion, alcohol consumption was a risk factor for having CCA in PSC patients. The indices of severity of liver disease were not associated with CCA in patients with PSC. Serum CA 19-9 appeared to have good ability to discriminate PSC patients with and without CCA.

AB - Patients with primary sclerosing cholangitis (PSC) have a significantly increased risk of developing cholangiocarcinoma (CCA). Risk factors for developing such a complication are not well defined. We conducted a multicenter, case-control study to determine the risk factors and possible predictors for CCA in patients with PSC. The demographic, clinical, and laboratory features of 26 PSC patients with CCA diagnosed over a 7-year period at eight academic centers were compared with 87 patients with PSC but no CCA (controls). There was no statistically significant difference in demographics, smoking, signs or symptoms or complications of PSC, indices of disease severity (Mayo Risk score or Child-Pugh score), frequency or duration or complications of inflammatory bowel disease (IBD), frequency of biliary surgery, or therapeutic endoscopy between the two groups. Alcohol consumption was significantly associated with CCA in patients with PSC (odds ratio: 2.95; 95% CI: 1.04-8.3). Serum carbohydrate antigen 19-9 (CA 19-9) was significantly higher in patients with CCA than those without (177 ± 89 and 61 ± 58 U/mL, respectively; P = .002). A serum CA 19-9 level > 100 U/mL had 75% sensitivity and 80% specificity in identifying PSC patients with CCA. In conclusion, alcohol consumption was a risk factor for having CCA in PSC patients. The indices of severity of liver disease were not associated with CCA in patients with PSC. Serum CA 19-9 appeared to have good ability to discriminate PSC patients with and without CCA.

UR - http://www.scopus.com/inward/record.url?scp=17544380026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17544380026&partnerID=8YFLogxK

M3 - Article

VL - 31

SP - 7

EP - 11

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 1

ER -