Cholesterol and APOE genotype interact to influence Alzheimer disease progression

R. M. Evans, Siu Hui, A. Perkins, Debomoy Lahiri, J. Poirier, Martin Farlow

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

In this retrospective analysis of 443 Alzheimer disease (AD) patients from a 30-week tacrine trial, change in Alzheimer's Disease Assessment Scale score from baseline to final value was significantly associated with a total serum cholesterol/APOE genotype interaction. Disease progression in the no-APOE ε4 allele/high-cholesterol subgroup was greater than in the normal-cholesterol subgroups with or without ε4. Cholesterol levels and APOE genotype may interact to affect AD progression. The results are consistent with preclinical data on cholesterol's effects in AD.

Original languageEnglish
Pages (from-to)1869-1871
Number of pages3
JournalNeurology
Volume62
Issue number10
StatePublished - May 25 2004

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Disease Progression
Alzheimer Disease
Cholesterol
Genotype
Tacrine
Alleles
Serum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cholesterol and APOE genotype interact to influence Alzheimer disease progression. / Evans, R. M.; Hui, Siu; Perkins, A.; Lahiri, Debomoy; Poirier, J.; Farlow, Martin.

In: Neurology, Vol. 62, No. 10, 25.05.2004, p. 1869-1871.

Research output: Contribution to journalArticle

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