Cholesterol and APOE genotype interact to influence Alzheimer disease progression

R. M. Evans, S. Hui, A. Perkins, D. K. Lahiri, J. Poirier, M. R. Farlow

Research output: Contribution to journalArticle

82 Scopus citations


In this retrospective analysis of 443 Alzheimer disease (AD) patients from a 30-week tacrine trial, change in Alzheimer's Disease Assessment Scale score from baseline to final value was significantly associated with a total serum cholesterol/APOE genotype interaction. Disease progression in the no-APOE ε4 allele/high-cholesterol subgroup was greater than in the normal-cholesterol subgroups with or without ε4. Cholesterol levels and APOE genotype may interact to affect AD progression. The results are consistent with preclinical data on cholesterol's effects in AD.

Original languageEnglish (US)
Pages (from-to)1869-1871
Number of pages3
Issue number10
StatePublished - May 25 2004

ASJC Scopus subject areas

  • Clinical Neurology

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