Cholesterol granulomas in lymph nodes draining a benign ovarian neoplasm

D. J. Grignon, M. E. Kirk, D. S.M. Haines

Research output: Contribution to journalArticle

5 Scopus citations


A 69-year-old woman underwent a hysterectomy and bilateral salpingo-oophorectomy for a 20-cm right ovarian tumor. Multiple peritoneal and lymph node biopsy specimens were obtained to determine the clinical stage. Despite the surgeon's concern of malignancy, pathologic examination demonstrated a benign mucinous cystadenoma. Periaortic and external iliac lymph nodes showed an unusual granulomatous reaction, with multinucleated giant cells surrounding cholesterol-like clefts. Analysis of cyst fluid from the ovarian tumor revealed high concentrations of protein and lipid; the lipid component was predominantly free cholesterol (0.61 μmole/mL) and phospholipid (0.225 μmole/mL). We speculate that fluid from the ovarian neoplasm drained into regional lymph nodes, causing this unusual granulomatous response.

Original languageEnglish (US)
Pages (from-to)1124-1126
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number12
StatePublished - Dec 1 1985

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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    Grignon, D. J., Kirk, M. E., & Haines, D. S. M. (1985). Cholesterol granulomas in lymph nodes draining a benign ovarian neoplasm. Archives of Pathology and Laboratory Medicine, 109(12), 1124-1126.