Cholesterol sulfate imaging in human prostate cancer tissue by desorption electrospray ionization mass spectrometry

Livia S. Eberlin, Allison L. Dill, Anthony B. Costa, Demian R. Ifa, Liang Cheng, Timothy Masterson, Michael Koch, Timothy L. Ratliff, R. Graham Cooks

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

Development of methods for rapid distinction between cancerous and non-neoplastic tissues is an important goal in disease diagnosis. To this end, desorption electrospray ionization mass spectrometry (DESI-MS) imaging was applied to analyze the lipid profiles of thin tissue sections of 68 samples of human prostate cancer and normal tissue. The disease state of the tissue sections was determined by independent histopathological examination. Cholesterol sulfate was identified as a differentiating compound, found almost exclusively in cancerous tissues including tissue containing precancerous lesions. The presence of cholesterol sulfate in prostate tissues might serve as a tool for prostate cancer diagnosis although confirmation through larger and more diverse cohorts and correlations with clinical outcome data is needed.

Original languageEnglish (US)
Pages (from-to)3430-3434
Number of pages5
JournalAnalytical Chemistry
Volume82
Issue number9
DOIs
StatePublished - May 1 2010

ASJC Scopus subject areas

  • Analytical Chemistry

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