Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women

A pilot study

Julie A. Dumas, Brenna McDonald, Andrew Saykin, Thomas W. McAllister, Mary L. Hynes, John D. West, Paul A. Newhouse

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: The cholinergic system has been shown to modulate estrogen effects on cognitive performance in postmenopausal women. In an effort to further understand cholinergic contributions to cognition after menopause, this pilot study investigated the effects of two receptor-specific anticholinergic drugs on brain activation and episodic memory encoding in postmenopausal women not taking estrogen. Methods: Six healthy postmenopausal women took part in three drug challenges using the antimuscarinic drug scopolamine (2.5 μg/kg IV), the antinicotinic drug mecamylamine (20 mg PO), and placebo. During functional magnetic resonance imaging, participants performed a visual-verbal continuous recognition memory test that allowed for the separation of encoding and recognition processes. Results: Functional magnetic resonance imaging results showed greater hippocampal and frontal activation and less occipital activation during encoding relative to retrieval conditions. This pattern of activation was similar under both drug challenges. Conclusions: These results suggest that the changes in the cholinergic system may, in part, be responsible for menopause-related increases in brain activation.

Original languageEnglish
Pages (from-to)852-859
Number of pages8
JournalMenopause
Volume17
Issue number4
DOIs
StatePublished - 2010

Fingerprint

Episodic Memory
Cholinergic Agents
Pharmaceutical Preparations
Menopause
Estrogens
Magnetic Resonance Imaging
Mecamylamine
Muscarinic Antagonists
Scopolamine Hydrobromide
Brain
Cholinergic Antagonists
Cognition
Placebos

Keywords

  • Cholinergic system
  • Episodic memory
  • Functional magnetic resonance imaging
  • Postmenopausal women

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women : A pilot study. / Dumas, Julie A.; McDonald, Brenna; Saykin, Andrew; McAllister, Thomas W.; Hynes, Mary L.; West, John D.; Newhouse, Paul A.

In: Menopause, Vol. 17, No. 4, 2010, p. 852-859.

Research output: Contribution to journalArticle

Dumas, Julie A. ; McDonald, Brenna ; Saykin, Andrew ; McAllister, Thomas W. ; Hynes, Mary L. ; West, John D. ; Newhouse, Paul A. / Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women : A pilot study. In: Menopause. 2010 ; Vol. 17, No. 4. pp. 852-859.
@article{6d884b6d23174a94ba36d978b380ad76,
title = "Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women: A pilot study",
abstract = "Objective: The cholinergic system has been shown to modulate estrogen effects on cognitive performance in postmenopausal women. In an effort to further understand cholinergic contributions to cognition after menopause, this pilot study investigated the effects of two receptor-specific anticholinergic drugs on brain activation and episodic memory encoding in postmenopausal women not taking estrogen. Methods: Six healthy postmenopausal women took part in three drug challenges using the antimuscarinic drug scopolamine (2.5 μg/kg IV), the antinicotinic drug mecamylamine (20 mg PO), and placebo. During functional magnetic resonance imaging, participants performed a visual-verbal continuous recognition memory test that allowed for the separation of encoding and recognition processes. Results: Functional magnetic resonance imaging results showed greater hippocampal and frontal activation and less occipital activation during encoding relative to retrieval conditions. This pattern of activation was similar under both drug challenges. Conclusions: These results suggest that the changes in the cholinergic system may, in part, be responsible for menopause-related increases in brain activation.",
keywords = "Cholinergic system, Episodic memory, Functional magnetic resonance imaging, Postmenopausal women",
author = "Dumas, {Julie A.} and Brenna McDonald and Andrew Saykin and McAllister, {Thomas W.} and Hynes, {Mary L.} and West, {John D.} and Newhouse, {Paul A.}",
year = "2010",
doi = "10.1097/gme.0b013e3181e04db9",
language = "English",
volume = "17",
pages = "852--859",
journal = "Menopause",
issn = "1072-3714",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Cholinergic modulation of hippocampal activity during episodic memory encoding in postmenopausal women

T2 - A pilot study

AU - Dumas, Julie A.

AU - McDonald, Brenna

AU - Saykin, Andrew

AU - McAllister, Thomas W.

AU - Hynes, Mary L.

AU - West, John D.

AU - Newhouse, Paul A.

PY - 2010

Y1 - 2010

N2 - Objective: The cholinergic system has been shown to modulate estrogen effects on cognitive performance in postmenopausal women. In an effort to further understand cholinergic contributions to cognition after menopause, this pilot study investigated the effects of two receptor-specific anticholinergic drugs on brain activation and episodic memory encoding in postmenopausal women not taking estrogen. Methods: Six healthy postmenopausal women took part in three drug challenges using the antimuscarinic drug scopolamine (2.5 μg/kg IV), the antinicotinic drug mecamylamine (20 mg PO), and placebo. During functional magnetic resonance imaging, participants performed a visual-verbal continuous recognition memory test that allowed for the separation of encoding and recognition processes. Results: Functional magnetic resonance imaging results showed greater hippocampal and frontal activation and less occipital activation during encoding relative to retrieval conditions. This pattern of activation was similar under both drug challenges. Conclusions: These results suggest that the changes in the cholinergic system may, in part, be responsible for menopause-related increases in brain activation.

AB - Objective: The cholinergic system has been shown to modulate estrogen effects on cognitive performance in postmenopausal women. In an effort to further understand cholinergic contributions to cognition after menopause, this pilot study investigated the effects of two receptor-specific anticholinergic drugs on brain activation and episodic memory encoding in postmenopausal women not taking estrogen. Methods: Six healthy postmenopausal women took part in three drug challenges using the antimuscarinic drug scopolamine (2.5 μg/kg IV), the antinicotinic drug mecamylamine (20 mg PO), and placebo. During functional magnetic resonance imaging, participants performed a visual-verbal continuous recognition memory test that allowed for the separation of encoding and recognition processes. Results: Functional magnetic resonance imaging results showed greater hippocampal and frontal activation and less occipital activation during encoding relative to retrieval conditions. This pattern of activation was similar under both drug challenges. Conclusions: These results suggest that the changes in the cholinergic system may, in part, be responsible for menopause-related increases in brain activation.

KW - Cholinergic system

KW - Episodic memory

KW - Functional magnetic resonance imaging

KW - Postmenopausal women

UR - http://www.scopus.com/inward/record.url?scp=77954913419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954913419&partnerID=8YFLogxK

U2 - 10.1097/gme.0b013e3181e04db9

DO - 10.1097/gme.0b013e3181e04db9

M3 - Article

VL - 17

SP - 852

EP - 859

JO - Menopause

JF - Menopause

SN - 1072-3714

IS - 4

ER -