Cholinergic regulation of mood and REM sleep: Potential model and marker of vulnerability to affective disorder

N. Sitaram, John Nurnberger, E. S. Gershon, J. C. Gillin

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

To test the hypothesis that depression and REM sleep share common cholinergic mechanisms the authors administered arecoline 25 min after completion of the first REM period to 14 patients with remitted bipolar affective disorder, 15 normal controls, and 5 subjects with a personal or family history of affective disorder. The second REM period occurred significantly sooner in the remitted patients than in the normal controls. The patients also had a significantly higher density of eye movements during the first REM period and a higher percentage of REM sleep. The authors believe that increased cholinergic sensitivity and REM density may be biological markers of increased vulnerability to bipolar affective illness.

Original languageEnglish (US)
Pages (from-to)571-576
Number of pages6
JournalAmerican Journal of Psychiatry
Volume139
Issue number5
StatePublished - 1982
Externally publishedYes

Fingerprint

REM Sleep
Mood Disorders
Cholinergic Agents
Arecoline
Eye Movements
Bipolar Disorder
Biomarkers
Depression

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Cholinergic regulation of mood and REM sleep : Potential model and marker of vulnerability to affective disorder. / Sitaram, N.; Nurnberger, John; Gershon, E. S.; Gillin, J. C.

In: American Journal of Psychiatry, Vol. 139, No. 5, 1982, p. 571-576.

Research output: Contribution to journalArticle

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