Chorioamnionitis and subsequent lung function in preterm infants

Marcus H. Jones, Andréa L. Corso, Robert Tepper, Maria I A Edelweiss, Luciana Friedrich, Paulo M C Pitrez, Renato T. Stein

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To explore the relationship between prematurity, gender and chorioamnionitis as determinants of early life lung function in premature infants. Methods: Placenta and membranes were collected from preterm deliveries (,37 weeks gestational age) and evaluated for histological chorioamnionitis (HCA). Patients were followed and lung function was performed in the first year of life by Raised Volume-Rapid Thoracic Compression Technique. Results: Ninety-five infants (43 males) born prematurely (median gestational age 34.2 weeks) were recruited. HCA was detected in 66 (69%) of the placentas, and of these 55(58%) were scored HCA Grade 1, and 11(12%) HCA Grade 2. Infants exposed to HCA Grade 1 and Grade 2, when compared to those not exposed, presented significantly lower gestational ages, higher prevalence of RDS, clinical early-onset sepsis, and the use of supplemental oxygen more than 28 days. Infants exposed to HCA also had significantly lower maximal flows. There was a significant negative trend for z-scores of lung function in relation to levels of HCA; infants had lower maximal expiratory flows with increasing level of HCA. (p = 0.012 for FEF50, p= 0.014 for FEF25-75 and p =0.32 for FEV0.5). Two-way ANOVA adjusted for length and gestational age indicated a significant interaction between sex and HCA in determining expiratory flows (p<0.01 for FEF50, FEF25-75 and p<0.05 for FEV0.5). Post-hoc comparisons revealed that female preterm infants exposed to HCA Grade 1 and Grade 2 had significant lower lung function than those not exposed, and this effect was not observed among males. Conclusions: Our findings show a sex-specific negative effect of prenatal inflammation on lung function of female preterm infants. This study confirms and expands knowledge upon the known association between chorioamnionitis and early life chronic lung disease.

Original languageEnglish
Article numbere81193
JournalPLoS One
Volume8
Issue number12
DOIs
StatePublished - Dec 5 2013

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Chorioamnionitis
lung function
Premature Infants
gestational age
Lung
placenta
gender
Gestational Age
premature birth
Pulmonary diseases
chest
Analysis of variance (ANOVA)
respiratory tract diseases
Placenta
analysis of variance
inflammation
Oxygen
Membranes
oxygen
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Jones, M. H., Corso, A. L., Tepper, R., Edelweiss, M. I. A., Friedrich, L., Pitrez, P. M. C., & Stein, R. T. (2013). Chorioamnionitis and subsequent lung function in preterm infants. PLoS One, 8(12), [e81193]. https://doi.org/10.1371/journal.pone.0081193

Chorioamnionitis and subsequent lung function in preterm infants. / Jones, Marcus H.; Corso, Andréa L.; Tepper, Robert; Edelweiss, Maria I A; Friedrich, Luciana; Pitrez, Paulo M C; Stein, Renato T.

In: PLoS One, Vol. 8, No. 12, e81193, 05.12.2013.

Research output: Contribution to journalArticle

Jones, MH, Corso, AL, Tepper, R, Edelweiss, MIA, Friedrich, L, Pitrez, PMC & Stein, RT 2013, 'Chorioamnionitis and subsequent lung function in preterm infants', PLoS One, vol. 8, no. 12, e81193. https://doi.org/10.1371/journal.pone.0081193
Jones MH, Corso AL, Tepper R, Edelweiss MIA, Friedrich L, Pitrez PMC et al. Chorioamnionitis and subsequent lung function in preterm infants. PLoS One. 2013 Dec 5;8(12). e81193. https://doi.org/10.1371/journal.pone.0081193
Jones, Marcus H. ; Corso, Andréa L. ; Tepper, Robert ; Edelweiss, Maria I A ; Friedrich, Luciana ; Pitrez, Paulo M C ; Stein, Renato T. / Chorioamnionitis and subsequent lung function in preterm infants. In: PLoS One. 2013 ; Vol. 8, No. 12.
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