Choroidal perfusion perturbations in non-neovascular age related macular degeneration

Thomas A. Ciulla, Alon Harris, Larry Kagemann, Ronald P. Danis, Linda M. Pratt, Hak S. Chung, Dov Weinberger, Hanna J. Garzozi

Research output: Contribution to journalArticle

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Abstract

Aim: Choroidal perfusion, affected in age related macular degeneration (AMD), is difficult to objectively assess given the overlying retinal circulation. This study more objectively compared choroidal perfusion parameters in a group with non-neovascular AMD to an unaffected age matched control group. Methods: 21 non-neovascular AMD subjects and 21 age matched control subjects without evidence of AMD underwent assessment of their choroidal blood flow in a case-control study. Scanning laser ophthalmoscope indocyanine green (ICG) angiograms were analysed by a new area dilution analysis technique. Four areas in the perifoveal region and two areas in the temporal peripapillary retina were evaluated by producing a graph of intensity of fluorescence of each area over time. The mean of the filling times and the heterogeneity of the filling times were assessed. Results: The means of the filling times within the perifoveal regions and the hetereogeneity of the filling times between regions within the same eyes were significantly greater in the AMD patients compared with the control subjects. Conclusions: Delayed and heterogeneous filling of the choroid was objectively demonstrated in eyes with non-neovascular AMD compared with age matched controls without evidence of AMD, using an area dilution analysis technique applied to ICG angiography.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalBritish Journal of Ophthalmology
Volume86
Issue number2
DOIs
StatePublished - 2002

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Macular Degeneration
Perfusion
Indicator Dilution Techniques
Indocyanine Green
Angiography
Ophthalmoscopes
Choroid
Retina
Case-Control Studies
Lasers
Research Design
Fluorescence
Control Groups

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ciulla, T. A., Harris, A., Kagemann, L., Danis, R. P., Pratt, L. M., Chung, H. S., ... Garzozi, H. J. (2002). Choroidal perfusion perturbations in non-neovascular age related macular degeneration. British Journal of Ophthalmology, 86(2), 209-213. https://doi.org/10.1136/bjo.86.2.209

Choroidal perfusion perturbations in non-neovascular age related macular degeneration. / Ciulla, Thomas A.; Harris, Alon; Kagemann, Larry; Danis, Ronald P.; Pratt, Linda M.; Chung, Hak S.; Weinberger, Dov; Garzozi, Hanna J.

In: British Journal of Ophthalmology, Vol. 86, No. 2, 2002, p. 209-213.

Research output: Contribution to journalArticle

Ciulla, TA, Harris, A, Kagemann, L, Danis, RP, Pratt, LM, Chung, HS, Weinberger, D & Garzozi, HJ 2002, 'Choroidal perfusion perturbations in non-neovascular age related macular degeneration', British Journal of Ophthalmology, vol. 86, no. 2, pp. 209-213. https://doi.org/10.1136/bjo.86.2.209
Ciulla, Thomas A. ; Harris, Alon ; Kagemann, Larry ; Danis, Ronald P. ; Pratt, Linda M. ; Chung, Hak S. ; Weinberger, Dov ; Garzozi, Hanna J. / Choroidal perfusion perturbations in non-neovascular age related macular degeneration. In: British Journal of Ophthalmology. 2002 ; Vol. 86, No. 2. pp. 209-213.
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