Chromosomal gains in the sarcomatoid transformation of chromophobe renal cell carcinoma

Matteo Brunelli, Stefano Gobbo, Paolo Cossu-Rocca, Liang Cheng, Ondrej Hes, Brett Delahunt, Maurizio Pea, Franco Bonetti, Maria M. Mina, Vincenzo Ficarra, Marco Chilosi, John N. Eble, Fabio Menestrina, Guido Martignoni

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

The hallmark of chromophobe renal cell carcinoma is multiple chromosomal losses from among chromosomes 1, 2, 6, 10 and 17. Chromophobe renal cell carcinoma with distant metastases or sarcomatoid transformation are uncommon and little is known about their chromosomal abnormalities. We collected six sarcomatoid chromophobe renal cell carcinomas and three primary chromophobe renal cell carcinomas with distant metastases. A cytogenetic analysis by fluorescent in situ hybridization on paraffin-embedded tissue was performed using centromeric probes for chromosomes 1, 2, 6, 10 and 17. We found more than one signal in four of six (66%) sarcomatoid chromophobe renal cell carcinomas, in both sarcomatoid and adjacent epithelial components. Both primary chromophobe renal cell carcinomas and matched metastases showed single signals for all chromosomes studied in two cases and no abnormalities in the remaining case. We concluded that: (1) both epithelial and sarcomatoid components of sarcomatoid chromophobe renal cell carcinoma show different genetic abnormalities from those characteristic of chromophobe renal cell carcinoma; (2) sarcomatoid chromophobe renal cell carcinomas frequently have multiple gains (polysomy) of chromosomes 1, 2, 6, 10 and 17; (3) distant metastases show the same genetic patterns, usually chromosomal losses (monosomy), found in the primary tumors.

Original languageEnglish (US)
Pages (from-to)303-309
Number of pages7
JournalModern Pathology
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2007

Keywords

  • Cytogenetic
  • FISH
  • Metastases
  • Sarcomatoid chromophobe renal carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Brunelli, M., Gobbo, S., Cossu-Rocca, P., Cheng, L., Hes, O., Delahunt, B., Pea, M., Bonetti, F., Mina, M. M., Ficarra, V., Chilosi, M., Eble, J. N., Menestrina, F., & Martignoni, G. (2007). Chromosomal gains in the sarcomatoid transformation of chromophobe renal cell carcinoma. Modern Pathology, 20(3), 303-309. https://doi.org/10.1038/modpathol.3800739